Regulatory role of adenine nucleotides in the biosynthesis of guanosine 5'-monophosphate.

Journal of Bacteriology
H J Nijkamp

Abstract

Derepression of the synthesis of inosine 5'-monophosphate (IMP) dehydrogenase and of xanthosine 5'-monophosphate (XMP) aminase in pur mutants of Escherichia coli which are blocked in the biosynthesis of adenine nucleotides and guanine nucleotides differs in two ways from derepression in pur mutants blocked exclusively in the biosynthesis of guanine nucleotides. (i) The maximal derepression is lower, and (ii) a sharp decrease in the specific activities of AMP dehydrogenase and XMP aminase occurs, following maximal derepression. From the in vivo and in vitro experiments described, it is shown that the lack of adenine nucleotides in derepressed pur mutants blocked in the biosynthesis of adenine and guanine nucleotides is responsible for these two phenomena. The adenine nucleotides are shown to play an important regulatory role in the biosynthesis of guanosine 5'-monophosphate (GMP). (i) They induce the syntheses of IMP dehydrogenase and XMP aminase. (The mechanism of induction may involve the expression of the gua operon.) (ii) They appear to have an activating function in IMP dehydrogenase and XMP aminase activity. The physiological importance of these regulatory characteristics of adenine nucleotides in the biosynthesis of GMP i...Continue Reading

References

Aug 22, 1967·Biochimica Et Biophysica Acta·H J Nijkamp, P G De Haan
Dec 1, 1967·Bacteriological Reviews·A L Taylor, C D Trotter
Jul 14, 1968·Journal of Molecular Biology·H J Nijkamp, A A Oskamp
Nov 1, 1965·Genetical Research·A H StouthamerH J Nijkamp
Jul 1, 1966·Genetics·M DemerecP E Hartman
Aug 1, 1955·Biochimica Et Biophysica Acta·E F NEUFELDS P COLOWICK

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Citations

Sep 1, 1973·Journal of Bacteriology·P R Lambden, W T Drabble
Dec 1, 1985·Journal of Bacteriology·A I Kessler, J S Gots
Sep 22, 1975·Biochimica Et Biophysica Acta·C E Benson, J S Gots
Oct 17, 1974·Biochimica Et Biophysica Acta·E W HolmesW N Kelley

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