PMID: 15240730Jul 9, 2004Paper

Regulatory role of C5a on macrophage migration inhibitory factor release from neutrophils

The Journal of Immunology : Official Journal of the American Association of Immunologists
Niels C RiedemannP A Ward

Abstract

There is evidence that C5a and macrophage migration inhibitory factor (MIF) both play important roles in experimental sepsis. Humans with sepsis also show elevated levels of both mediators in the blood. Regulation of MIF during sepsis is poorly understood. We now demonstrate that neutrophil depletion greatly reduced serum MIF levels in rats and mice during the onset of sepsis after cecal ligation and puncture. In vitro, C5a induced MIF release from rat and mouse neutrophils. In vivo blockade of C5aR or absence of C5aR led to significantly reduced MIF generation during the onset of sepsis. C5a-induced release in vitro of MIF from neutrophils appeared to be due to up-regulation of MIF in cytoplasmic granules of neutrophils via activation of the protein kinase B signaling pathway together with involvement of PI3K. Our data suggest that C5a plays a role in enhancing MIF release from neutrophils in vitro and during sepsis. These findings represent a previously unrecognized function of C5a and neutrophils in the appearance of MIF in sepsis.

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Citations

Jul 25, 2006·The Journal of Biological Chemistry·Arezoo DaryadelShida Yousefi
Sep 26, 2006·Journal of Leukocyte Biology·Ren-Feng GuoPeter A Ward
Jun 27, 2014·BioMed Research International·Hagen SchmalNiels Riedemann
Mar 18, 2005·Annual Review of Immunology·Ren-Feng Guo, Peter A Ward
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laszlo M HoeselPeter A Ward
May 14, 2009·Der Internist·H P Hauber, P Zabel
Mar 28, 2009·American Journal of Respiratory and Critical Care Medicine·Andrew Conway MorrisA John Simpson
Sep 20, 2008·Nature Reviews. Immunology·Daniel RittirschPeter A Ward
Jul 1, 2014·British Journal of Pharmacology·Prashant ShuklaPrabhat Ranjan Mishra
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christiane D WrannNiels C Riedemann
Aug 4, 2011·Seminars in Immunopathology·Katerina OikonomopoulouJohn D Lambris
Apr 12, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Markus BosmannPeter A Ward
Jul 10, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Chandra BhanPranita P Sarangi
Sep 24, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Oliver SommerfeldAdrian T Press
Aug 8, 2021·Cancers·Yaiza SenentBeatriz Tavira

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