Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum

American Journal of Physiology. Heart and Circulatory Physiology
Tepmanas Bupha-Intr, Jonggonnee Wattanapermpool

Abstract

Alterations in the intracellular Ca2+ handling in cardiomyocytes may underlie the cardiac dysfunction observed in the ovarian sex hormone-deprived condition. To test the hypothesis that ovarian sex hormones had a significant role in the cardiac intracellular Ca2+ mobilization, the sarcoplasmic reticulum (SR) Ca2+ uptake and SR Ca2+-ATPase (SERCA) activity were determined in 10-wk ovariectomized rat hearts. With the use of left ventricular homogenate preparations, a significant suppression of maximum SR Ca2+ uptake activity, but with an increase in SR Ca2+ responsiveness, was demonstrated in ovariectomized hearts. In parallel measurements of SERCA activity in SR-enriched membrane preparations from ovariectomized hearts, a suppressed maximum SERCA activity with a leftward shift in the relationship between pCa (-log molar free Ca2+ concentration) and SERCA activity was also detected. A significant downregulation of SERCA proteins and reduction in the SERCA mRNA level were observed in association with suppressed maximum SERCA activity. While there were no changes in total phospholamban and phosphorylated Ser16 phospholamban levels, a decrease in phosphorylated Thr17 phospholamban as well as an increase in the suprainhibitory, monom...Continue Reading

References

Jul 1, 1987·Circulation Research·J ScheuerJ Capasso
Feb 1, 1995·Pflügers Archiv : European journal of physiology·S HeyderJ C Rüegg
Jul 15, 1993·The American Journal of Cardiology·A PinesD Ayalon
Aug 5, 1998·The American Journal of Physiology·J CernohorskýR Vetter
Dec 5, 1998·The Journal of Biological Chemistry·G ChuE G Kranias
Aug 13, 1999·The American Journal of Physiology·J Wattanapermpool, P J Reiser
Jul 5, 2001·Journal of Molecular and Cellular Cardiology·R DashE G Kranias
Feb 20, 2002·Trends in Cardiovascular Medicine·Dirk Hagemann, Rui-Ping Xiao
Dec 31, 2002·Cardiovascular Research·Konrad F FrankRobert H G Schwinger
Jan 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jun RenHuawei Zeng
Feb 26, 2003·Circulation Research·Valentino PiacentinoSteven R Houser
Jun 14, 2003·TheScientificWorldJournal·Angel Zarain-Herzberg, Georgina Alvarez-Fernández
Oct 8, 2003·Pflügers Archiv : European journal of physiology·Klara BrixiusRobert H G Schwinger
Dec 16, 2003·Journal of Applied Physiology·Tepmanas Bupha-Intr, Jonggonnee Wattanapermpool
Apr 16, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Larry N PetzAnn M Nardulli
Jul 17, 2004·Molecular Endocrinology·Kari M H DoyleJoAnne S Richards
Aug 18, 2004·Journal of the American College of Cardiology·Khuram W ChaudharyKenneth B Margulies
Sep 1, 2004·Biochemical and Biophysical Research Communications·Kobra HaghighiEvangelia G Kranias
Feb 12, 2005·Science·Chetana M RevankarEric R Prossnitz

❮ Previous
Next ❯

Citations

Feb 19, 2013·Pflügers Archiv : European journal of physiology·Randi J Parks, Susan E Howlett
Sep 3, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·E BesnierB Dureuil
Dec 8, 2009·European Heart Journal·Samuel Sclarovsky, Kjell Christer Nikus
Jan 26, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elizabeth A TownsendY S Prakash
Apr 26, 2011·Reproductive Biology and Endocrinology : RB&E·Altemar S PaigelIvanita Stefanon
Mar 30, 2013·Biology of Sex Differences·Virginia M MillerWalter A Rocca
Jul 5, 2012·Endocrinology·Christopher D HainesLeslie A Leinwand
Jan 12, 2013·PloS One·Rogerio Faustino RibeiroIvanita Stefanon
Apr 30, 2014·The Journal of Physiological Sciences : JPS·Sulaksana PanditTepmanas Bupha-Intr
Jan 28, 2014·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Maciej WybraniecLukasz Krzych
Apr 17, 2013·Pflügers Archiv : European journal of physiology·Jonggonnee WattanapermpoolToni R Pak
Apr 9, 2013·Heart Failure Clinics·Sebastian SzardienHolger M Nef
Jul 17, 2012·Experimental Physiology·Ronald D BeesleyMichael J Toth
May 12, 2009·Ageing Research Reviews·Monika Puzianowska-Kuznicka, Jacek Kuznicki
Jan 28, 2014·European Journal of Heart Failure·Sven MeyerMaarten P van den Berg
Apr 2, 2014·Clinical and Experimental Pharmacology & Physiology·Brent J F Hill, Edwin Muldrew
Jun 24, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Katja E Odening, Gideon Koren
Sep 24, 2011·Journal of Molecular and Cellular Cardiology·Elias FaresSusan E Howlett
Dec 17, 2014·Menopause : the Journal of the North American Menopause Society·Gábor Artúr DunayZsuzsanna Miklós
Jun 19, 2013·The Journal of Steroid Biochemistry and Molecular Biology·James R BellLea M D Delbridge
Aug 16, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·David Hauton
Dec 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Chutima RattanasopaTepmanas Bupha-Intr
Nov 13, 2014·Hormone Molecular Biology and Clinical Investigation·Roger Lyrio dos SantosIvanita Stefanon
Sep 18, 2016·Heart Failure Clinics·Rupert WilliamsAbhiram Prasad
Jan 25, 2017·Journal of Cardiovascular Medicine·Gabriele PizzinoConcetta Zito
Mar 3, 2010·Nature Reviews. Cardiology·Holger M NefChristian W Hamm
Oct 14, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ariyaporn ThawornkaiwongJonggonnee Wattanapermpool
Oct 14, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tepmanas Bupha-IntrR J Solaro
Dec 4, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Namthip WitayavanitkulJonggonnee Wattanapermpool
Feb 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Tepmanas Bupha-IntrJonggonnee Wattanapermpool
Feb 23, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Lijuan JiaoHong Sun
Mar 12, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sukanya PhungphongTepmanas Bupha-Intr
Aug 31, 2006·British Journal of Pharmacology·T Korte, C Grohé
Oct 16, 2008·Clinical Science·Dominica ZentnerStephen B Harrap
Sep 26, 2014·American Journal of Physiology. Cell Physiology·Karni S MoshalGideon Koren
Aug 6, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Hsiang-Yu YangKenneth T MacLeod
Jan 30, 2020·Frontiers in Endocrinology·Leanne GrobanSarah H Lindsey
Aug 15, 2015·Journal of Applied Physiology·Pavarana Vutthasathien, Jonggonnee Wattanapermpool

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.