Regulatory role of vitamin D receptor gene variants of Bsm I, Apa I, Taq I, and Fok I polymorphisms on macrophage phagocytosis and lymphoproliferative response to mycobacterium tuberculosis antigen in pulmonary tuberculosis

Journal of Clinical Immunology
P SelvarajP R Narayanan

Abstract

The regulatory role of vitamin D receptor (VDR) gene variants of Bsm I, Apa I, Taq I, and Fok I polymorphisms on vitamin D(3)-modulated macrophage phagocytosis with live Mycobacterium tuberculosis and lymphoproliferative response to M. tuberculosis culture filtrate antigen (CFA) was studied in patients with pulmonary tuberculosis (n = 46) and in normal healthy subjects (NHS) (n = 64). Vitamin D(3) at a concentration of 1 x 10(-7) M enhanced the phagocytic potential of normal subjects who had a phagocytic index of less than 20%. This increase was seen in subjects with the genotypes BB (p = 0.017), AA (p = 0.016), tt (p = 0.034), and FF (p = 0.013) and the extended genotype BBAAtt (p = 0.034). Normal subjects with BBAAtt performed better phagocytosis than individuals with bbaaTT genotype (p = 0.034). Vitamin D(3) at 10(-9), 10(-8), and 10(-7) M concentrations suppressed the lymphoproliferative response to CFA antigen in normal subjects. This decreased lymphocyte response was observed in normal individuals with the genotypes BB (p = 0.0009), tt (p = 0.016), and FF (p = 0.008) and the extended genotype BBAAtt (p = 0.02). Addition of vitamin D(3) had no significant effect on macrophage phagocytosis and lymphoproliferative response t...Continue Reading

Citations

Nov 12, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·V C C ChengK Y Yuen
Jan 22, 2008·The Journal of Infectious Diseases·Manuel Sánchez de la TorreJoan Fibla
Feb 13, 2008·The Journal of Infectious Diseases·Daniel E RothSunita Vohra
Dec 14, 2011·Interactive Cardiovascular and Thoracic Surgery·Akif TurnaAtilla Gurses
Apr 24, 2009·Nutrition Reviews·Patricia Chocano-Bedoya, Alayne G Ronnenberg
Mar 27, 2010·International Journal of Dentistry·Marja L LaineW Crielaard
Jun 12, 2012·Italian Journal of Pediatrics·Ismail YildizSalih Aydin
Dec 29, 2010·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·R VijayalakshmiPamela Emmadi
Feb 28, 2014·Genetic Testing and Molecular Biomarkers·Mohammad Yahya AreeshiShafiul Haque
Sep 1, 2005·Journal of Clinical Periodontology·Bruno G LoosMarja L Laine
Aug 11, 2006·Journal of Clinical Periodontology·Kyung Sook ParkJeomil Choi
Dec 3, 2011·Periodontology 2000·Marja L LaineBruno G Loos
Mar 28, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jose M Valdivielso, Elvira Fernandez
Jun 11, 2015·Journal of Chemotherapy·Ludovica FacchiniElena Chiappini
Jan 13, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C C H WieldersR Janssen
Jul 19, 2011·Archives of Oral Biology·F S MartelliE Fanti
Sep 11, 2012·The American Journal of Pathology·Selvakumar SubbianGilla Kaplan
Aug 16, 2011·Der Internist·S J Ott, S Schreiber
Nov 2, 2015·BMC Infectious Diseases·Susanna Esposito, Mara Lelii
May 26, 2009·Journal of Bacteriology·Omar H VandalSabine Ehrt
Mar 25, 2009·International Journal of Immunopathology and Pharmacology·S ArdizzoneG Bianchi Porro
Aug 5, 2009·Molecular Diagnosis & Therapy·Seetha V BalasinghamTone Tønjum
Oct 2, 2015·Basic & Clinical Pharmacology & Toxicology·Marie-Louise OvesjöLinda Björkhem-Bergman
Sep 9, 2017·BMC Infectious Diseases·María Teresa HerreraMartha Torres
Feb 14, 2019·BMC Oral Health·Zahra HeidariHamidreza Mahmoudzadeh-Sagheb
Feb 18, 2015·Basic & Clinical Pharmacology & Toxicology·Stina BettsLena Ekström
Apr 27, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Upendra YadavVandana Rai
Oct 28, 2016·Microbiology Spectrum·Vivek Naranbhai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.