Regulatory roles of junctin in sarcoplasmic reticulum calcium cycling and myocardial function.

Trends in Cardiovascular Medicine
Guo-Chang FanEvangelia G Kranias

Abstract

Junctin (JCN), a 26-kd sarcoplasmic reticulum (SR) transmembrane protein, forms a quaternary protein complex with the ryanodine receptor, calsequestrin, and triadin in the SR lumen of cardiac muscle. Within this complex, calsequestrin, triadin, and JCN appear to be critical for normal regulation of ryanodine receptor-mediated calcium (Ca) release. Junctin and triadin exhibit 60% to 70% amino acid homology in their transmembrane domains, including repeated KEKE motifs important for macromolecular protein-protein interactions within their SR luminal tails. Recent studies have uncovered functional roles of both JCN and triadin in the mouse heart, using transgenic overexpression strategies, which exhibit varying phenotypes including mild SR structural alterations, prolongation of Ca transient decay, impaired relaxation, and cardiac hypertrophy and/or heart failure. More specifically, both in vitro adenoviral gene transfer and in vivo gene-targeting techniques to manipulate JCN expression levels have shown that JCN is an essential factor in maintaining normal cardiac Ca handling and cardiac function. This article reviews the new findings on the regulatory roles of JCN in cardiac SR Ca cycling and contractility, with special emphasis...Continue Reading

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Citations

Nov 7, 2009·PLoS Computational Biology·Nathan SalomonisBruce R Conklin
Jul 2, 2009·The Journal of Physiology·Angela DulhuntyNicole Beard
Jun 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Junqiang YeTom Maniatis
Dec 7, 2010·Life Sciences·Terry S EltonDmitry Terentyev
May 5, 2009·Trends in Cell Biology·Marek Michalak, Michal Opas
Apr 25, 2012·Clinical and Experimental Pharmacology & Physiology·Angela F DulhuntyNicole A Beard
Apr 2, 2010·BMB Reports·Dukgyu Lee, Marek Michalak
Jan 1, 2014·The International Journal of Biochemistry & Cell Biology·Robyn T RebbeckAngela F Dulhunty

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