Regulatory roles of leptin at the hypothalamic-hypophyseal axis before and after sexual maturation in cattle

Biology of Reproduction
D A ZiebaG L Williams


Studies assessed, either directly or indirectly, the role of GnRH in leptin-mediated stimulation of LH release in cattle before and after sexual maturation. In experiment 1, the objectives were to determine whether leptin could acutely accelerate the frequency of LH pulses, and putatively GnRH pulses, in prepubertal heifers at different stages of development. In experiment 2, we determined directly whether acute, leptin-mediated increases in LH secretion in the fasted, mature female are accompanied by an increase in GnRH secretion. Ten-month-old prepubertal heifers (experiment 1) fed normal- (n = 5) and restricted-growth (n = 5) diets received three injections of saline or recombinant ovine leptin (oleptin; 0.2 microg/kg body weight, i.v.) at hourly intervals during 5-h experiments conducted every 5 wk until all normal-growth heifers were pubertal. Leptin increased mean concentrations of circulating LH regardless of diet, but pulse characteristics were not altered at any age. In experiment 2, ovariectomized, estradiol-implanted cows (n = 5) were fasted twice for 72 h and treated with either saline or oleptin i.v. (as in experiment 1) on Day 3 of each fast. Leptin increased plasma concentrations of LH and third ventricle cerebro...Continue Reading


Dec 1, 1992·Journal of Animal Science·K K SchilloS M Hileman
Mar 1, 1991·Statistics in Medicine·R H Kushler, M B Brown
Feb 1, 1986·Biology of Reproduction·R P AmannT M Nett
Mar 1, 1988·Journal of Reproduction and Fertility·S E DodsonG E Lamming
Feb 1, 1997·Endocrinology·C C CheungR A Steiner
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·W H YuS M McCann
May 13, 1999·Brain Research·D G BaskinM A Miller
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·N D QuintonR J Ross
Mar 23, 2000·Theriogenology·S M Kappes
Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·J E HallK A Martin
Jul 7, 2000·Frontiers in Neuroendocrinology·R S AhimaJ K Elmquist
Jul 27, 2002·Domestic Animal Endocrinology·G L WilliamsD H Keisler
Feb 13, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Hilary DobsonRobert Smith
Mar 11, 2003·Experimental Biology and Medicine·Dorota A ZiebaGary L Williams

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