Regulatory T-cell dynamics with abatacept treatment in rheumatoid arthritis

International Reviews of Immunology
Kane Langdon, Nagaraja Haleagrahara

Abstract

The progressive damage in rheumatoid arthritis (RA) has been linked to an increase in inflammatory Th1/Th17 cells and a decrease in number or function of immunomodulatory regulatory T cells (Tregs). Many therapies that are effective in RA are shown to affect Th1/Th17 cells and/or Tregs. One such therapy, abatacept, utilizes a physiologic immunomodulatory molecule called cytotoxic lymphocyte antigen-4 (CTLA-4) which causes contact-dependent inhibition of inflammatory T-cell activation. Recent advances in CTLA-4 research has uncovered the method by which this occurs physiologically but the actions of the CTLA-4Ig fusion protein are still not fully understood. The reported effects of the drug on Treg population number and suppressor function have been very mixed. In this review, we will discuss the current literature surrounding the effects of abatacept in rheumatoid arthritis and explore potential explanations for the differences in results. Future opportunities in this area include contributions to a unified definition for different immune cell populations, LAG3+ Tregs which may pose an avenue for further study or the stratification of patients with regards to their specific disease characteristics, resulting in optimized treatm...Continue Reading

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Citations

Jul 10, 2019·Calcified Tissue International·Stephanie R HarrisonMartin Hewison
Sep 22, 2018·International Reviews of Immunology·Himanshu Kumar, Adrian Bot
Mar 20, 2019·International Journal of Molecular Sciences·Shyi-Jou ChenHuey-Kang Sytwu
May 15, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin EichmannCraig A Beam
Jul 4, 2020·The European Respiratory Journal·Emmanuel Stephen-VictorJagadeesh Bayry
Mar 6, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·John D MountzAndre Ballesteros-Tato
Feb 12, 2019·Frontiers in Immunology·Romy E Hoeppli, Anne M Pesenacker
Jan 16, 2022·Inflammopharmacology·Kane LangdonNagaraja Haleagrahara

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