Apr 30, 2017

Regulatory T Cell Immunity in Atherosclerosis

Acta Medica Indonesiana
Hilman Zulkifli AminKen-Ichi Hirata

Abstract

Atherosclerosis is a chronic inflammatory disorder involving innate and adaptive immunity process. Effector T cell (Teff) responses promote atherosclerotic disease, whereas regulatory T cells (Tregs) have been shown to play a protective role against atherosclerosis by down-regulating inflammatory responses which include multiple mechanisms. Compelling experimental data suggest that shifting the Treg/Teff balance toward Tregs may be a possible therapeutic approach for atherosclerotic disease, although the role of Tregs in human atherosclerotic disease has not been fully elucidated. In this review, we discuss recent advances in our understanding of the roles of Tregs and Teffs in experimental atherosclerosis, as well as human coronary artery disease.

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Mentioned in this Paper

Chronic Inflammatory Disorder
CD4+ CD25+ Regulatory T Cells
Eragrostis
Coronary Artery Disease
Chronic Inflammation
Equilibrium
Coronary Arteriosclerosis
Atherogenesis
Adaptive Immunity
Carotid Artery Diseases

About this Paper

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