Regulatory T Cell Immunotherapy in Immune-Mediated Diseases

Current Stem Cell Reports
Antonio PieriniRobert S Negrin

Abstract

Broad clinical interest rapidly followed the recent discovery of different subpopulations of T cells that have immune regulatory properties and a number of studies have been conducted aiming to dissect the translational potential of these promising cells. In this review we will focus on forkhead box P3 (FoxP3) positive regulatory T cells, T regulatory type 1 cells and invariant natural killer T cells (iNKT). We will analyze their ability to correct immune dysregulation in animal models of immune mediated diseases and we will examine the first clinical approaches where these cells have been directly or indirectly employed. We will discuss successes, challenges and limitations that rose in the road to the clinical use of regulatory T cells.

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Citations

Aug 3, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Rumi IshiiKazunari Tanabe
Mar 16, 2018·Frontiers in Immunology·Antonella MancusiAntonio Pierini
Oct 20, 2017·JCI Insight·Antonio PieriniEverett H Meyer

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