Regulatory T cell-mediated control of autoantibody-induced inflammation.

Frontiers in Immunology
Keishi FujioKazuhiko Yamamoto

Abstract

Autoimmune inflammation including autoantibody-induced inflammation is responsible for the lethal organ damage. Autoantibody-induced inflammation can be separated in two components, autoantibody production, and local inflammatory responses. Accumulating evidence has suggested that regulatory T cells (Treg) control both antibody production and the numbers and functions of effector cells such as innate cells and T helper cells. Autoantibodies are produced by both the follicular and extrafollicular pathways. Recently, follicular regulatory T cells (T(FR)) and Qa-1 restricted CD8(+) Treg were identified as populations that are capable of suppressing follicular T helper cell (T(FH))-mediated antibody production. In local inflammation, CD4(+)CD25(+)Foxp3(+) Treg have the capacity to control inflammation by suppressing cytokine production in T helper cells. Although complement proteins contribute to autoantibody-induced local inflammation by activating innate cells, Treg including CD4(+)CD25(+)Foxp3(+) Treg are able to suppress innate cells, chiefly via IL-10 production. IL-10-secreting T cells such as T regulatory type I (Tr1) and Tr1-like cells might also play roles in the control of Th17 and innate cells. Therefore, several kinds o...Continue Reading

Citations

Apr 29, 2015·Autoimmunity Reviews·Tessa DhaezeNiels Hellings
Sep 26, 2013·Acta Microbiologica Et Immunologica Hungarica·Vesna Kovačević-JovanovićMirjana Dimitrijević
Jun 1, 2016·Human Immunology·Peter BorosMargit Zeher
Oct 27, 2016·Scandinavian Journal of Immunology·Z SuJ Wang
Mar 16, 2019·Immunological Reviews·Válter R FonsecaLuis Graca
May 17, 2019·The Journal of Clinical Endocrinology and Metabolism·Xinyu XuTao Yang
Nov 10, 2018·Frontiers in Immunology·Marisa StebeggLuis Graca
Mar 30, 2018·Frontiers in Medicine·Dirlei NicoAlexandre Morrot
Nov 30, 2018·Frontiers in Cellular Neuroscience·Heather K HughesPaul Ashwood
Aug 30, 2020·American Journal of Clinical Dermatology·Emily M Altman
Jan 24, 2019·Mediators of Inflammation·Huijuan Ma, Chang-Qing Xia
Jul 10, 2019·International Journal of Immunopathology and Pharmacology·Farshid FathiHossein Motedayyen

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