Jul 12, 2020

Regulatory T Cell Metabolism in Atherosclerosis

Metabolites
Jeroen Baardman, Esther Lutgens

Abstract

Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a chronic inflammatory disease of the arterial wall and the leading cause of cardiovascular disease. Therefore, therapeutic strategies to improve Treg number or function could be beneficial to preventing atherosclerotic disease development. A growing body of evidence shows that intracellular metabolism of Tregs is a key regulator of their proliferation, suppressive function, and stability. Here we evaluate the role of Tregs in atherosclerosis, their metabolic regulation, and the links between their metabolism and atherosclerosis.

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Mentioned in this Paper

Metabolism
Suppression, Genetic
Autoimmune Diseases
Cardiovascular Diseases
Chronic Inflammation
Wall of Artery
Chronic Inflammatory Disorder
Regulation of T Cell Activation
Immune Response
Atherosclerosis

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