Regulatory T Cell-Related Gene Biomarkers in the Deterioration of Atherosclerosis.

Frontiers in Cardiovascular Medicine
Meng XiaCheng Qian

Abstract

Background: Regulatory T cells (Tregs) have shown to be protective against the development of atherosclerosis, a major pathological cause for cardiovascular events. Here, we aim to explore the roles of Tregs-related genes in atherosclerosis deterioration. Methods and Results: We downloaded the gene expression profile of 29 atherosclerotic samples from the Gene Expression Omnibus database with an accession number of GSE28829. The abundance of Tregs estimated by the CIBERSORT algorithm was negatively correlated with the atherosclerotic stage. Using the limma test and correlation analysis, a total of 159 differentially expressed Tregs-related genes (DETregRGs) between early and advanced atherosclerotic plaques were documented. Functional annotation analysis using the DAVID tool indicated that the DETregRGs were mainly enriched in inflammatory responses, immune-related mechanisms, and pathways such as complement and coagulation cascades, platelet activation, leukocyte trans-endothelial migration, vascular smooth muscle contraction, and so on. A protein-protein interaction network of the DETregRGs was then constructed, and five hub genes (PTPRC, C3AR1, CD53, TLR2, and CCR1) were derived from the network with node degrees ≥20. The ex...Continue Reading

References

Jul 28, 2004·Immunology Letters·Nicholas D Huntington, David M Tarlinton
Jun 3, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Marianna PapaspyridonosLisa Patel
Sep 5, 2006·Cellular and Molecular Life Sciences : CMLS·V Braunersreuther, F Mach
Dec 2, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Vincent BraunersreutherChristian Weber
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jun 12, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Enrico AmmiratiGiuseppe Danilo Norata
Aug 4, 2010·Autoimmunity Reviews·S SitiaM Turiel
Nov 1, 2012·PloS One·Colin J ComerciJordan S Orange
Dec 22, 2012·The Journal of Clinical Investigation·Manikandan SubramanianIra Tabas
Dec 19, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ramiro MalgorDouglas J Goetz
Jan 5, 2014·Circulation Research·Carlos Silvestre-RoigOliver Soehnlein
Mar 31, 2015·Nature Methods·Aaron M NewmanAsh A Alizadeh
Oct 2, 2015·Comprehensive Physiology·Nikolaos G Frangogiannis
Dec 8, 2015·Current Medicinal Chemistry·Juntang LinXinjie Lu
Apr 26, 2017·International Journal of Rheumatic Diseases·Chunhui MaChengqin Yi
Oct 17, 2017·Cardiovascular Research·Daniel EngelbertsenEva Bengtsson
Jan 13, 2018·Acta Pharmacologica Sinica·Han-Xiao OuZhong-Cheng Mo
Oct 15, 2018·Journal of Cellular Physiology·Edoardo EliaFederico Carbone
Nov 8, 2018·BMC Bioinformatics·Momeneh ForoutanMelissa J Davis
Jan 18, 2019·Circulation Research·Dennis Wolf, Klaus Ley
Nov 20, 2019·International Journal of Molecular Sciences·Armand JaminonLeon Schurgers
Apr 28, 2020·Circulation Research·Monika SharmaKathryn J Moore
Aug 9, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Lin-Lin WeiKe Li
Aug 24, 2020·The Journal of Allergy and Clinical Immunology·Anh N DoSupinda Bunyavanich
Sep 29, 2020·Circulation Research·Marie A C DepuydtGerard Pasterkamp
Nov 13, 2020·Annals of Translational Medicine·Mathilde MuraAntoine Millon
Dec 4, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Holger Winkels, Dennis Wolf
Dec 15, 2020·Journal of the American College of Cardiology·Gregory A RothUNKNOWN GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group
Feb 26, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Ibadete BytyçiMichael Y Henein

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

CIBERSORT
pROC
Pheatmap
DETregRGs
Search Tool for the
Cytoscape
R
DAVID
limma

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.