Regulatory T cells in human disease and their potential for therapeutic manipulation.

Immunology
Leonie S TaamsCatherine M Hawrylowicz

Abstract

Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory pathologies in vivo. At a recent meeting [Clinical Application of Regulatory T Cells, 7-8 April 2005, Horsham, UK, organized by the authors of this review, in collaboration with the British Society for Immunology and Novartis] evidence was discussed that certain human autoimmune, infectious and allergic diseases are associated with impaired regulatory T-cell function. In contrast, evidence from several human cancer studies and some infections indicates that regulatory T cells may impair the development of protective immunity. Importantly, certain therapies, both those that act non-specifically to reduce inflammation and antigen-specific immunotherapies, may induce or enhance regulatory T-cell function. The purpose of this review was to summarize current knowledge on regulatory T-cell function in human disease, and to assess critically how this can be tailored to suit the therapeutic manipulation of immunity.

References

Jan 1, 1997·The Annals of Thoracic Surgery·S WanJ L Vincent
Jul 3, 1998·The Journal of Clinical Investigation·C A AkdisK Blaser
Feb 24, 2001·The Journal of Experimental Medicine·M V DhodapkarN Bhardwaj
Jun 29, 2001·Trends in Immunology·H JonuleitA H Enk
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S GregoriL Adorini
Aug 30, 2001·Nature Immunology·K J Maloy, F Powrie
Nov 28, 2001·Immunological Reviews·M G RoncaroloM K Levings
Feb 14, 2002·The Journal of Allergy and Clinical Immunology·Catherine HawrylowiczTak Lee
Mar 22, 2002·Nature Reviews. Immunology·Leonid Gorelik, Richard A Flavell
Apr 20, 2002·Science·Maria YazdanbakhshRonald van Ree
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edward Y WooCarl H June
Jun 5, 2002·Nature Reviews. Cancer·Samuel R Denmeade, John T Isaacs
Jul 13, 2002·European Journal of Immunology·Leonie S TaamsArne N Akbar
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Udaya K LiyanageDavid C Linehan
Mar 5, 2003·European Journal of Immunology·Chia-Huey Lin, Thomas Hünig
Mar 27, 2003·Nature Reviews. Immunology·Kathryn J Wood, Shimon Sakaguchi
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian MottetFiona Powrie
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Iris BellinghausenJoachim Saloga
Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Giao Q PhanSteven A Rosenberg
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea CavaniGiampiero Girolomoni
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Berent J PrakkenSalvatore Albani
Mar 24, 2004·Seminars in Immunology·Herman WaldmannYuki Tone
Apr 7, 2004·The Journal of Experimental Medicine·Vissia VigliettaDavid A Hafler
May 1, 2004·The Journal of Experimental Medicine·Martin A KriegelHanns-Martin Lorenz
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ismé M de KleerBerent Prakken
May 8, 2004·The Journal of Allergy and Clinical Immunology·Machteld M TiemessenEls Van Hoffen
Jun 16, 2004·The Journal of Experimental Medicine·Malin R KarlssonPer Brandtzaeg
Jul 1, 2004·Arthritis Research & Therapy·Duojia CaoVivianne Malmström
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manuelle ViguierLaurent Ferradini

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Citations

Jan 12, 2007·Gene Therapy·G J Prud'hommeQ Wang
Aug 30, 2008·Thyroid : Official Journal of the American Thyroid Association·J Paul BangaLaszlo Hegedus
Jan 4, 2013·Clinical and Vaccine Immunology : CVI·Riccardo V D'EliaGraeme C Clark
Dec 26, 2006·Journal of Bacteriology·Erin C BoyleB Brett Finlay
Oct 6, 2010·Canadian Journal of Microbiology·Nooshin SohrabiZahra Gheflati
Apr 18, 2013·American Journal of Respiratory and Critical Care Medicine·Patricia L SempleKeertan Dheda
Mar 17, 2009·Clinical and Molecular Allergy : CMA·Subhadra NandakumarUday Kumaraguru
Jan 1, 2010·Multidisciplinary Respiratory Medicine·Agnès HamzaouiKamel Hamzaoui
Mar 1, 2013·Arthritis Research & Therapy·Olivia WeigertGabriela Riemekasten
Jun 2, 2007·Journal of Periodontology·Jill M Kramer, Sarah L Gaffen
Oct 15, 2013·Journal of Pediatric Gastroenterology and Nutrition·Joo Hyun GilHye Youn Sung
Dec 1, 2006·Annual Review of Immunology·Gabriel A RabinovichEduardo M Sotomayor
Nov 9, 2007·Digestive Diseases and Sciences·Beate C SydoraRichard N Fedorak
Jul 28, 2011·Expert Review of Clinical Immunology·Jocea M R Michels-van AmelsfortLeonie S Taams
Dec 8, 2006·Expert Opinion on Biological Therapy·Ronald J Buckanovich
Jul 3, 2015·Experimental and Therapeutic Medicine·Qingming LuoL I Chen
Oct 1, 2015·The Journal of Investigative Dermatology·Hyun Gyu LeeByung-Hak Kim
Dec 23, 2011·Kidney International·Li-Wen LaiYeong-Hau H Lien
Mar 15, 2011·Pathology, Research and Practice·Nicola DanieleFrancesco Zinno
Jan 24, 2009·Biochimica Et Biophysica Acta·Peter C J JansonOla Winqvist
Jul 26, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·J Harness, P A McCombe
Oct 7, 2015·Scientific Reports·Reiner K W MailerJohn Andersson
Apr 9, 2008·European Journal of Immunology·Todd Brusko, Jeffrey Bluestone
Sep 26, 2008·The Journal of Gene Medicine·Melanie AlbrechtGerald Reese
Feb 14, 2009·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Attila Tárnok
Oct 5, 2010·International Journal of Dermatology·Enas A S AttiaHala B Ali
Jul 21, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Hsien-Tzung LiaoChung-Tei Chou
Jun 30, 2015·Hematology·Siti-Zuleha IdrisMaha Abdullah
Jul 8, 2015·Journal of Autoimmunity·Anne-Laure JolyJohn Andersson
Sep 25, 2014·American Journal of Respiratory Cell and Molecular Biology·Rosalinda SorrentinoAldo Pinto

❮ Previous
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