Regulatory T cells in renal disease

Clinical & Translational Immunology
Maliha A AlikhanJoshua D Ooi

Abstract

The kidney is vulnerable to injury, both acute and chronic from a variety of immune and metabolic insults, all of which at least to some degree involve inflammation. Regulatory T cells modulate systemic autoimmune and allogenic responses in glomerulonephritis and transplantation. Intrarenal regulatory T cells (Tregs), including those recruited to the kidney, have suppressive effects on both adaptive and innate immune cells, and probably also intrinsic kidney cells. Evidence from autoimmune glomerulonephritis implicates antigen-specific Tregs in HLA-mediated dominant protection, while in several human renal diseases Tregs are abnormal in number or phenotype. Experimentally, Tregs can protect the kidney from injury in a variety of renal diseases. Mechanisms of Treg recruitment to the kidney include via the chemokine receptors CCR6 and CXCR3 and potentially, at least in innate injury TLR9. The effects of Tregs may be context dependent, with evidence for roles for immunoregulatory roles both for endogenous Tbet-expressing Tregs and STAT-3-expressing Tregs in experimental glomerulonephritis. Most experimental work and some of the ongoing human trials in renal transplantation have focussed on unfractionated thymically derived Tregs (...Continue Reading

References

Nov 1, 1990·Kidney International·R J Falk
Mar 21, 1998·Kidney International·R D Toto
Jul 6, 2000·The Journal of Clinical Investigation·A M VanBuskirkC G Orosz
Jun 20, 2003·The New England Journal of Medicine·Billy G HudsonEric G Neilson
Jan 1, 1964·Acta Pathologica Japonica·T FUJIMOTO
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Lindsay S CairnsRobert N Barker
Mar 25, 2005·Journal of the American Society of Nephrology : JASN·Dominik WolfAlexander R Rosenkranz
Feb 10, 2006·Journal of the American Society of Nephrology : JASN·Yuan Min WangStephen I Alexander
Apr 21, 2006·Journal of the American Society of Nephrology : JASN·Matthew David MorganCaroline Savage
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Deepika MahajanDavid C H Harris
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaolei TangVipin Kumar
May 29, 2007·Arthritis and Rheumatism·Wayel H AbdulahadCees G M Kallenberg
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oriol BestardJosep M Grinyó
Feb 27, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Volker DanielGerhard Opelz
Oct 7, 2008·Nature Medicine·Renate KainDontscho Kerjaschki
Feb 24, 2009·Transplant Immunology·Rebecca M M MonteiroAlvaro Pacheco-Silva
May 19, 2009·Nature Medicine·Kai KessenbrockDieter E Jenne
Jun 6, 2009·Journal of the American Society of Nephrology : JASN·Gilbert R KinseyMark D Okusa
Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Jul 25, 2009·Kidney International·Maria Teresa GandolfoHamid Rabb
Mar 20, 2010·Journal of the American Society of Nephrology : JASN·Qi CaoDavid C H Harris
Mar 20, 2010·Journal of the American Society of Nephrology : JASN·Jan-Eric TurnerUlf Panzer
May 14, 2010·Kidney International·Hyojung LeeHyunsu Bae
Oct 19, 2010·Nature Immunology·Lauren W CollisonDario A A Vignali
Dec 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathrin EllerAnna M Wolf
Dec 24, 2010·Nephrology·Vincent W S Lee, David C H Harris
Jan 21, 2011·Kidney International·Joshua D OoiA Richard Kitching
Mar 26, 2011·The American Journal of Pathology·Masahiro MiyajimaRobert B Colvin
Apr 29, 2011·Kidney International·Hans-Joachim PaustGisa Tiegs
May 4, 2011·European Journal of Immunology·André HoerningDavid M Briscoe
May 6, 2011·Transplantation·G Alex BishopGeoffrey W McCaughan

❮ Previous
Next ❯

Citations

Apr 4, 2018·Clinical & Translational Immunology·Kirsten A Ward-Hartstonge, Ajithkumar Vasanthakumar
Jul 18, 2019·Journal of the American Society of Nephrology : JASN·Julia HagensteinOliver M Steinmetz
Sep 19, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Ciara Jade Bansal, Amolak Singh Bansal
Jul 14, 2018·Medicines·Ranmali Ranasinghe, Rajaraman Eri
Jul 4, 2020·Journal of the American Society of Nephrology : JASN·Simon MelderisOliver M Steinmetz
Feb 9, 2021·Frontiers in Medicine·Elisavet StavropoulouEugenia Bezirtzoglou
Apr 6, 2021·Frontiers in Medicine·Elisavet StavropoulouEugenia Bezirtzoglou
Aug 13, 2021·Frontiers in Immunology·Ryuichi Nagashima, Masayuki Iyoda

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
biopsies
flow cytometry
and
biopsy

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.