Regulatory T cells induced by Mycobacterium chelonae sensitization influence murine responses to bacille Calmette-Guerin

Journal of Leukocyte Biology
Peiying HoGeok Teng Seah

Abstract

The efficacy of live Mycobacterium bovis BCG as a tuberculosis vaccine is highly varied globally. Differential sensitization to environmental mycobacteria prior to BCG vaccination may prime immune effects leading to this variation, but the precise immune mechanisms and cell types involved in this phenomenon are unknown. We hypothesized that pre-vaccination sensitization to environmental mycobacteria induces mycobacterium-specific Tregs that suppress responses to BCG. This was investigated by testing Treg responses following priming of BALB/c mice by i.p. immunization with heat-killed CHE. Such mice produced higher levels of IL-10 before and after intranasal, live BCG administration and had fewer lung inflammatory cells post-BCG, relative to nonsensitized mice. In CHE-sensitized mice, the percentage of splenic CD4+CD25+ cells expressing Foxp3 amongst total lymphocytes was not elevated significantly, but these cells limited nonspecific proliferation of CD4+CD25⁻ effector cells upon coculture and promoted higher expression levels of CD103 and Foxp3 in response to BCG antigen stimulation than CD4+CD25+ cells from nonsensitized mice. In adoptive transfer experiments, naïve, WT mice receiving CD4+CD25+ cells from CHE-sensitized mice ...Continue Reading

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Citations

Dec 9, 2014·Human Vaccines & Immunotherapeutics·C PonteP R Z Antas
Oct 14, 2014·Frontiers in Microbiology·Jorjoh Ndure, Katie L Flanagan
Sep 9, 2016·Immunotherapy·Nancy GuptaRakesh Kumar
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Jul 8, 2015·Journal of Leukocyte Biology·Bastiaan A BlokMihai G Netea
Dec 3, 2010·Journal of Leukocyte Biology·Michelle M ColemanKingston H G Mills
Mar 2, 2021·Acta Microbiologica Et Immunologica Hungarica·Joana KorabliovieneArunas Valiulis

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