Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Bitao LiangRaphael Clynes

Abstract

Lymphocyte activation gene-3 (LAG-3) is a CD4-related transmembrane protein expressed by regulatory T cells that binds MHC II on APCs. It is shown in this study that during Treg:DC interactions, LAG-3 engagement with MHC class II inhibits DC activation. MHC II cross-linking by agonistic Abs induces an ITAM-mediated inhibitory signaling pathway, involving FcgammaRgamma and ERK-mediated recruitment of SHP-1 that suppresses dendritic cell maturation and immunostimulatory capacity. These data reveal a novel ITAM-mediated inhibitory signaling pathway in DCs triggered by MHC II engagement of LAG-3, providing a molecular mechanism in which regulatory T cells may suppress via modulating DC function.

References

Sep 1, 1994·Immunology Today·P R Scholl, R S Geha
May 22, 2002·Nature Immunology·Azusa UjikeToshiyuki Takai
Sep 11, 2002·European Journal of Immunology·Siyuan LiangAnatolij Horuzsko
Sep 5, 2002·European Journal of Immunology·Creg J WorkmanDario A A Vignali
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Creg J WorkmanDario A A Vignali
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine SedlikSebastian Amigorena
Mar 5, 2003·Annual Review of Immunology·Ralph M SteinmanMichel C Nussenzweig
Apr 3, 2003·European Journal of Immunology·Creg J Workman, Dario A A Vignali
Oct 28, 2003·Nature Immunology·Francesca FallarinoPaolo Puccetti
Jan 22, 2004·Current Opinion in Immunology·Reem Al-DaccakDominique Charron
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Creg J WorkmanDario A A Vignali
Sep 15, 2004·Trends in Immunology·Paola Mina-Osorio, Enrique Ortega
Oct 16, 2004·Immunity·Ching-Tai HuangDario A A Vignali
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nianyu LiDario A A Vignali
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Creg J Workman, Dario A A Vignali
Feb 25, 2005·The Journal of Experimental Medicine·Kazuya TakahashiHarald Neumann
May 17, 2005·Nature Immunology·Jessica A HamermanLewis L Lanier
Aug 11, 2005·Scandinavian Journal of Immunology·C-Q XiaM J Clare-Salzler
Dec 13, 2005·American Journal of Respiratory Cell and Molecular Biology·Shigeki MatsubaraErwin W Gelfand
Feb 2, 2006·Science's STKE : Signal Transduction Knowledge Environment·Jessica A Hamerman, Lewis L Lanier
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roch HouotSerge Lebecque
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anshu AgrawalBali Pulendran
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica A HamermanLewis L Lanier

❮ Previous
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Citations

Jun 21, 2008·Nature Reviews. Immunology·Dario A A VignaliCreg J Workman
Sep 9, 2008·The Journal of Clinical Investigation·Olivier ManchesNina Bhardwaj
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zuqiang LiuZhaoyang You
Nov 17, 2009·Immunological Reviews·Jessica A HamermanClifford A Lowell
Dec 4, 2009·International Reviews of Immunology·Brigitte SonierFraser W Scott
Oct 31, 2009·European Journal of Immunology·Pascal ChappertDavid-Alexandre Gross
Apr 13, 2010·Expert Review of Clinical Immunology·Fadi IssaKathryn J Wood
Feb 20, 2010·Mediators of Inflammation·Franco PandolfiGiovanni Cammarota
Apr 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katy DerbyshireDiane M Scott
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jingwei MaBo Huang
Nov 11, 2014·European Journal of Immunology·Carolina MooreAndrew Bushell
Aug 1, 2013·Clinical & Translational Immunology·David E GyorkiCharlotte E Ariyan
Sep 9, 2015·Frontiers in Immunology·Isabelle Le MercierRandolph J Noelle
Nov 8, 2015·Biochemistry. Biokhimii︠a︡·F Yu Garib, A P Rizopulu
Sep 24, 2015·Clinical and Experimental Immunology·Asiel Arce-SillasLaura Adalid-Peralta
Aug 15, 2015·Journal of Immunology Research·Yamei Wang, Yuhong Tao
Mar 2, 2016·Annual Review of Immunology·Susanne H BaumeisterArlene H Sharpe
Jan 27, 2016·World Journal of Gastroenterology : WJG·Christophe PedrosMarianne Chabod
Jun 15, 2016·Journal of Immunology Research·Asiel Arce-SillasLaura Adalid-Peralta
May 10, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Katarzyna BocianNadzieja Drela
Jun 13, 2017·Frontiers in Immunology·Leonn Mendes Soares PereiraAntonio Carlos Rosário Vallinoto
Jun 19, 2017·Cellular and Molecular Life Sciences : CMLS·Alexandra Kitz, Margarita Dominguez-Villar
Nov 21, 2017·Journal of Biomedical Science·Chien-Hui Chien, Bor-Luen Chiang
Jan 13, 2018·Acta Pharmacologica Sinica·Han-Xiao OuZhong-Cheng Mo
May 4, 2018·Oncotarget·Allison M MartinMichael Lim
Sep 5, 2018·Journal of Zhejiang University. Science. B·Sheng-Tao Zhao, Chang-Zheng Wang
Aug 15, 2018·The Journal of Clinical Investigation·Cameron McDonald-HymanBruce R Blazar
Feb 5, 2019·Immunopharmacology and Immunotoxicology·Soheil Najafi, Abbas Mirshafiey
Jan 18, 2019·PLoS Pathogens·Colin G GraydonKeith R Fowke
Sep 20, 2019·Immunological Reviews·Jason M GauthierDaniel Kreisel
Jan 11, 2020·Frontiers in Oncology·Wei MuMargot Zöller
Apr 18, 2020·BMC Immunology·Samantha S BeaufordCharlie Garnett-Benson
Jun 13, 2020·European Journal of Immunology·Florian DuboisRichard Danger
May 30, 2020·Cell Research·Xing He, Chenqi Xu
Sep 27, 2008·Current Rheumatology Reports·Sujata Sarkar, David A Fox
Nov 26, 2010·Autoimmunity·Elaine V Lourenço, Antonio La Cava

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