Regulatory T cells

Current Opinion in Pharmacology
Claire Thompson, F Powrie

Abstract

Regulatory T (TR) cells are a subset of T cells that function to control immune responses. Different populations of TR cells have been described, including thymically derived CD4(+)CD25+ TR cells and Tr1 cells induced in the periphery through exposure to antigen. A transcription factor, Foxp3, has been identified that is essential for CD4(+)CD25+ TR cell development and function. There is now evidence that transforming growth factor-beta might play a role in this pathway. CD4(+)CD25+ TR cells proliferate extensively in vivo in an antigen-specific manner, and can respond to both self and foreign peptides. By suppressing excessive immune responses, TR cells play a key role in the maintenance of self-tolerance, thus preventing autoimmune disease, as well as inhibiting harmful inflammatory diseases such as asthma and inflammatory bowel disease.

Citations

Mar 19, 2009·Archives of Dermatological Research·Tamer Irfan KayaGuliz Ikizoglu
Sep 17, 2008·Immunology and Cell Biology·Esma S YolcuShai Yarkoni
Sep 30, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sandra D Bohling, Kimberly H Allison
Mar 15, 2006·The Journal of Experimental Medicine·Carlos E TadokoroMichael L Dustin
Jun 23, 2005·Stem Cells and Development·Frank P BarryBernard P Mahon
Dec 3, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Francesco Chiappelli
Dec 8, 2006·Annals of the Rheumatic Diseases·Elena Gonzalez-ReyMario Delgado
Jul 28, 2005·Journal of Inflammation·Jennifer M RyanBernard P Mahon
Oct 31, 2012·International Journal of Molecular Sciences·Giovanni MonteleoneCarmine Stolfi
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Elena Gonzalez-ReyMario Delgado
Jun 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Amir SharabiEdna Mozes
Apr 5, 2008·Clinical & Developmental Immunology·Chang H Kim
Nov 22, 2005·Expert Opinion on Drug Delivery·Lothar Steidler
Jul 31, 2007·Experimental Eye Research·Karen M SijssensJoke H de Boer
Mar 27, 2007·Best Practice & Research. Clinical Gastroenterology·Karen RobinsonJohn C Atherton
Jan 6, 2007·Biochemical and Biophysical Research Communications·Youmin KangBin Wang
Jun 10, 2006·Hematology/oncology Clinics of North America·Kelvin P LeeEckhard R Podack
Apr 20, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W Karmaus, V Gangur
Jul 29, 2005·Immunological Reviews·Ana M C Faria, Howard L Weiner
Feb 1, 2005·Annals of the New York Academy of Sciences·Fiona Powrie
Mar 6, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Teruo MiyazakiYasushi Matsuzaki
Sep 14, 2007·Periodontology 2000·Yael Houri-HaddadLior Shapira
Jan 5, 2008·Oral Microbiology and Immunology·T OkuiK Yamazaki
Oct 24, 2006·Annals of the New York Academy of Sciences·Lothar Steidler, Pieter Rottiers
Oct 8, 2008·Immunological Reviews·Henry TabelMeiqing Shi
Sep 8, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Miodrag ColicAleksandra Lukic
Nov 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S SchweleH-D Volk
Apr 14, 2010·Scandinavian Journal of Immunology·B-L WangG-L Xu
Mar 7, 2014·Journal of Viral Hepatitis·S K WilliamsD P Webster
May 16, 2006·Gastroenterology·Elena Gonzalez-ReyMario Delgado

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