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Regulatory variants explain much more heritability than coding variants across 11 common diseases

bioRxiv

Apr 21, 2014

Alexander GusevAlkes L Price

Abstract

Common variants implicated by genome-wide association studies (GWAS) of complex diseases are known to be enriched for coding and regulatory variants. We applied methods to partition the heritability explained by genotyped SNPs (h2g) across functional categories (while accounting for sha...read more

Mentioned in this Paper

Genome-Wide Association Study
Genome
Schizophrenia
Deoxyhypusine synthase
Dysequilibrium Syndrome
Drug Hypersensitivity Syndrome
DNASE1
Analysis
Single Nucleotide Polymorphism
Hypersensitivity
77
69
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Regulatory variants explain much more heritability than coding variants across 11 common diseases

bioRxiv

Apr 21, 2014

Alexander GusevAlkes L Price

PMID: 990004309

DOI: 10.1101/004309

Abstract

Common variants implicated by genome-wide association studies (GWAS) of complex diseases are known to be enriched for coding and regulatory variants. We applied methods to partition the heritability explained by genotyped SNPs (h2g) across functional categories (while accounting for sha...read more

Mentioned in this Paper

Genome-Wide Association Study
Genome
Schizophrenia
Deoxyhypusine synthase
Dysequilibrium Syndrome
Drug Hypersensitivity Syndrome
DNASE1
Analysis
Single Nucleotide Polymorphism
Hypersensitivity
77
69

Similar Papers Found In These Feeds

Paper Details
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