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Regulatory variants explain much more heritability than coding variants across 11 common diseases

bioRxiv

Apr 21, 2014

Alexander Vasilyevich GusevAlkes L. Price

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Abstract

Common variants implicated by genome-wide association studies (GWAS) of complex diseases are known to be enriched for coding and regulatory variants. We applied methods to partition the heritability explained by genotyped SNPs (h2g) across functional categories (while accounting for sha...read more

Mentioned in this Paper

Genome
Hypersensitivity
Genetic Linkage
Schizophrenia
Deoxyhypusine synthase
Enhancer of transcription
Dysequilibrium Syndrome
Cohort
Gene Mutant
Single Nucleotide Polymorphism
77
69
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  • Regulatory variants explain much more heritability than coding variants across 11 common diseases

    bioRxiv

    Apr 21, 2014

    Alexander Vasilyevich GusevAlkes L. Price

    PMID: 990004309

    DOI: 10.1101/004309

    Abstract

    Common variants implicated by genome-wide association studies (GWAS) of complex diseases are known to be enriched for coding and regulatory variants. We applied methods to partition the heritability explained by genotyped SNPs (h2g) across functional categories (while accounting for sha...read more

    Mentioned in this Paper

    Genome
    Hypersensitivity
    Genetic Linkage
    Schizophrenia
    Deoxyhypusine synthase
    77
    69

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