Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Peter J KahrilasColin W Howden

Abstract

Although most patients with gastroesophageal reflux disease (GERD) achieve substantial symptom relief with acid suppression, many have some residual symptoms. We evaluated the responsiveness of regurgitation, characterized by the reflux disease questionnaire (RDQ) to potent acid suppression. We analyzed data from 2 randomized controlled trials of AZD0865 (a potassium-competitive acid blocker) 25-75 mg/day vs esomeprazole 20-40 mg/day for the treatment of nonerosive reflux disease (NERD, n = 1460) or reflux esophagitis (RE, n = 1514). Inclusion criteria for both studies were high-severity substernal burning (≥4 days per week of at least moderate intensity) during the week before enrollment. Pooled data from all treatment arms were used to ascertain the response of the reflux disease questionnaire regurgitation items to potent acid suppression during the fourth week of treatment. When the study began, 93% of patients with NERD or RE had either "acid taste in the mouth" (regurgitation-taste) or "unpleasant movement of material upwards from the stomach" (regurgitation-movement). Either or both symptoms were present and severe in 53% of NERD (n = 717) and 54% of RE patients (n = 751) for the main study outcome. During week 4 of ther...Continue Reading

References

Oct 24, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Peter J KahrilasGoran Hasselgren

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Citations

Apr 25, 2012·Langenbeck's Archives of Surgery·Christian A Gutschow, Arnulf H Hölscher
Sep 4, 2013·Best Practice & Research. Clinical Gastroenterology·Peter J KahrilasAndre J P M Smout
Jan 17, 2014·Current Treatment Options in Gastroenterology·Fehmi Ates, Michael F Vaezi
Mar 13, 2014·Gut·Guy BoeckxstaensPeter J Kahrilas
May 3, 2014·Surgical Endoscopy·Karl Hermann FuchsUNKNOWN European Association of Endoscopic Surgery (EAES)
Nov 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Wout O RohofGuy E Boeckxstaens
Feb 8, 2014·Gastroenterology Clinics of North America·David S Estores
Jun 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Robert A GanzDan Dunn
Oct 6, 2015·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Greta SainoRobert A Ganz
Jul 22, 2014·Alimentary Pharmacology & Therapeutics·P J KahrilasC W Howden
Nov 15, 2013·Journal of Gastroenterology and Hepatology·Jae Hoon YangChoon Jo Jin
Dec 22, 2014·Gastroenterology·Prateek Sharma, Philip Katz
Jun 20, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T V K HerregodsA J P M Smout
Dec 17, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Boudewijn F KessingAndré J P M Smout
Jun 23, 2015·Journal of the American College of Surgeons·Jessica L ReynoldsJohn C Lipham
Oct 3, 2014·Gastroenterology Report·Charumathi Raghu Subramanian, George Triadafilopoulos
Jan 15, 2015·Postgraduate Medical Journal·Guy BoeckxstaensPeter J Kahrilas
Jun 22, 2016·The American Journal of Gastroenterology·Karthik Ravi, David A Katzka
Mar 28, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael F VaeziNicholas J Shaheen
Apr 22, 2014·Expert Review of Gastroenterology & Hepatology·Fehmi AtesMichael F Vaezi
Mar 1, 2018·Scandinavian Journal of Gastroenterology·Waseem M SeleemSamir I Mohamed
Nov 8, 2017·Digestive Diseases and Sciences·Yu-Min KungYao-Kuang Wang
Feb 9, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Edy SofferMichael D Crowell
Jan 16, 2013·The American Journal of Gastroenterology·Nicholas J ShaheenDebra G Silberg
Feb 1, 2019·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Young Chan LeeYoung-Gyu Eun
Aug 7, 2017·Current Gastroenterology Reports·C Prakash Gyawali
Apr 8, 2020·Expert Review of Clinical Pharmacology·Vincenzo SavarinoEdoardo Savarino
May 10, 2020·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Manuel E Sanchez-Casalongue, Timothy M Farrell
Jul 30, 2017·Expert Opinion on Pharmacotherapy·Edoardo SavarinoVincenzo Savarino
Apr 4, 2013·Current Opinion in Gastroenterology·Philip Woodland, Daniel Sifrim
Sep 19, 2014·World Journal of Gastroenterology : WJG·Shou-Wu LeeChi-Sen Chang
May 6, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·K-H FuchsG Varga

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