Rehabilitation of motor dysfunction in primary brain tumor patients†

Neuro-oncology Practice
David S Kushner, Christina Amidei

Abstract

In 2010 it was estimated that >688 000 Americans were living with a primary brain tumor (PBT) corresponding to a U.S. prevalence rate of approximately 221.8 per 100 000 people. Five-year survival is 96.1% in nonmalignant PBTs, 34% in malignant PBTs for all ages, and 71% in children [1985-2005]. Case fatality rates have decreased in the U.S. since the 1970's for nonmalignant PBTs and for medulloblastoma, oligodendroglioma, and astrocytoma. Statistics of increasing survival highlight the importance of rehabilitation interventions to improve function and quality of life in survivors. PBT motor dysfunction is multifactorial, occurring as a result of direct effects of tumor and/or swelling or as a result of treatments; etiologies include encephalopathy, myopathy, neuropathy, infection, poor nutrition, metabolic factors, emotional factors, impaired perception/vision/cognition and complications of immobility. Motor dysfunction may lead to: impaired mobility, impaired activities of daily living, risk for complications of immobility, falls, pain, anxiety/depression, and loss of functional independence and quality of life. Rehabilitation treatment strategies target specific causes of motor dysfunction to improve functional independence a...Continue Reading

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Citations

Jul 27, 2018·PloS One·Taylla Klei Felix SouzaLionel Fernel Gamarra
Jun 25, 2019·Frontiers in Genetics·Amal KatribJeremy A Miller
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Nov 11, 2021·Cancer Medicine·Rebecca A HarrisonEduardo Bruera

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