Reinfection hazard of hand-foot-mouth disease in Wuhan, China, using Cox-proportional hazard model

Epidemiology and Infection
Y PengJ Gong

Abstract

Hand-foot-mouth disease (HFMD) is an acute infectious disease caused by serotypes of the enterovirus (EV) family. HFMD reinfection occurs commonly in lack of cross-protection between different EV serotypes. In this study, we investigated the hazards of HFMD reinfection using Cox-proportional hazard model. Retrospective data of 95 209 HFMD cases in Wuhan during 2008-2015 was used. Kaplan-Meier survival methods and Cox-proportional hazard model were used to estimate the hazard probabilities. Of the all HFMD cases, about 2% experienced reinfection (1842/95 209). Kaplan-Meier curves revealed the reinfection risk sharply increased before 40 months from first infection. Higher hazards of reinfection were detected among those who were males, aged 3 years and below, scattered children, belonging to urban areas and first infected with coxsackievirus (CV)-A16 compared with their respective counterparts. Cox-proportional hazard model suggested that gender, age, group, living area and serotypes of first infection had significant effect on reinfection even after adjusting for potential confounding effects of other selected factors considered in the study. These results indicate that boys aged 3 years and below, especially those living in ur...Continue Reading

References

Oct 22, 2008·Lancet·Longde WangMary Elizabeth Wilson
Sep 1, 2011·Epidemiology and Infection·M ZengQ-R Zhu
Dec 27, 2011·Journal of Neurosurgery. Spine·Wesley HsuGary L Gallia
Feb 4, 2014·The Lancet Infectious Diseases·Weijia XingHongjie Yu
Dec 18, 2014·Nature

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