Reinforcement magnitude modulates the rate-dependent effects of fluvoxamine and desipramine on fixed-interval responding in the pigeon

Behavioural Pharmacology
R J Lamb, Brett C Ginsburg

Abstract

Some doses of fluvoxamine can decrease ethanol-maintained behavior more than food-maintained behavior. This might be explained by differences in reinforcement magnitude. In a previous study, the effects of fluvoxamine on fixed-ratio responding did not depend upon reinforcement magnitude. Response rates, however, differed with reinforcement magnitude. These differences in response rates might explain the failure to observe differences in the potency of fluvoxamine with changes in reinforcement magnitude. In this study, we examined whether the effects of fluvoxamine and desipramine depended on the reinforcement magnitude and response rate, by administering these drugs to pigeons responding under a multiple fixed-interval schedule, in which responding in three components was maintained by differing durations of food presentation (2, 4, and 8 s). The effects of fluvoxamine and desipramine depended jointly on control rate, reinforcement magnitude, and dose. Low fluvoxamine doses had rate-dependent effects in all three components, increasing lower rates more than higher rates: as dose increased, these rate-dependent effects became greater in the components maintained by the 2-s or 4-s food presentation; whereas, in the component main...Continue Reading

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Nov 23, 2006·Experimental and Clinical Psychopharmacology·Brett C Ginsburg, R J Lamb

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Citations

Aug 6, 2009·Experimental and Clinical Psychopharmacology·Jonathan W PinkstonR J Lamb
Jun 29, 2011·Experimental and Clinical Psychopharmacology·Brett C GinsburgR J Lamb
Nov 21, 2008·Behavioural Pharmacology·Brett C Ginsburg, Richard J Lamb
Aug 15, 2014·Behavioural Pharmacology·Jonathan W PinkstonRichard J Lamb
Nov 13, 2012·Journal of the Experimental Analysis of Behavior·Jonathan W Pinkston, R J Lamb

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