Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin

International Journal of Cosmetic Science
Z ZhangD J Lunter

Abstract

The aim of the study was to develop formulations to deliver physiological lipids into skin in an attempt to repair defective barrier function. Physiological cholesterol and linoleic acid were incorporated into basic cream and non-ionic cream to prepare skin repair formulations. Homogeneity and storage stability of the developed creams were examined by polarized light microscopy. Ex vivo evaluation was conducted using lipid-deficient skin samples and confocal Raman microspectroscopy. A 7-day in vivo study was performed on volunteers to study the repairing efficacy. Homogeneous texture was seen in the prepared skin repair formulations. The application of the creams led to substantially increased lipid levels compared to the reference in the lipid-deficient skin in ex vivo study. Twice-a-day application of the skin repair creams provided a reinforcement of the skin barrier as transepidermal water loss (TEWL) was significantly decreased. The skin repair creams showed excellent efficacy in skin recovery. They have great potentials for treating impaired skin barrier associated with depletion of lipids in stratum corneum.

References

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