Reinforcement of hydrogel scaffold using oxidized-guar gum incorporated with curcumin-loaded zein nanoparticles to improve biological performance.

International Journal of Biological Macromolecules
Parinaz Nezhad-MokhtariNima Abdyazdani

Abstract

Newly, the use of biocompatible injectable hydrogel with appropriate features for application in the tissue engineering area as a perfect wound dressing has been more attracted. For this purpose, the curcumin loaded Zein nanoparticles/aldehyde-modified guar gum/silk fibroin (Cur-NPs/OGG/SF) hydrogel networks were successfully developed to increase the Cur bioavailability during the wound treatment procedure. Fabricated hydrogels were assessed for their morphological, thermal stability, degradation, and mechanical features. By varying the OGG/SF weight ratios, the physicochemical features of hydrogels without or with Cur-loaded Zein NPs were studied. The results showed that with enhancing the OGG content, the degradation behavior of hydrogels were improved. Besides, Cur-NPs/OGG/SF hydrogels increased the cell proliferation without any cytotoxic effect on mouse embryonic fibroblast (NIH-3T3) cells. The Cur-NPs/OGG/SF hydrogel exposed inhibition activity against Bacillus (15.26 ± 1.09 mm) and E. coli (11.54± 1.36 mm) bacteria. These achieved results recommended that the novel developed hydrogel could be suitable for wound healing application.

References

May 11, 2004·Biomacromolecules·Rina NazarovDavid L Kaplan
Dec 9, 2004·Biomaterials·Ung-Jin KimDavid L Kaplan
Aug 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R A SharmaW P Steward
Mar 8, 2008·Cellular and Molecular Life Sciences : CMLS·H HatcherS V Torti
Oct 12, 2010·Journal of Colloid and Interface Science·Chengjun ZhouQuanguo Zhang
Nov 10, 2012·Advanced Drug Delivery Reviews·Banani KunduXungai Wang
Nov 28, 2012·Advanced Healthcare Materials·Naresh Kasoju, Utpal Bora
May 18, 2016·International Journal of Biological Macromolecules·Veera Venkata Satyanarayana Reddy KarriRajkumar Malayandi
Feb 24, 2018·Frontiers in Chemistry·Mônica PascoliLeonardo F Fraceto
May 17, 2018·Trends in Biotechnology·Mehdi FarokhiDavid L Kaplan
May 31, 2019·International Journal of Biological Macromolecules·Mohammadreza RostamiSoghra Ramezani
Aug 11, 2019·International Journal of Biological Macromolecules·Parinaz Nezhad-MokhtariJafar Soleimani Rad
Aug 27, 2019·ACS Applied Materials & Interfaces·Yan ChengHaiyuan Zhang
Nov 9, 2019·Nature Physics·Robert J TetleyYanlan Mao
Mar 11, 2020·International Journal of Biological Macromolecules·Marjan GhorbaniSoghra Ramazani
Mar 19, 2020·International Journal of Biological Macromolecules·Parinaz Nezhad-MokhtariMarjan Ghorbani
Jun 2, 2020·International Journal of Biological Macromolecules·Mohammad Akrami-Hasan-KohalBehzad Nikzad
Jun 3, 2020·Communications Biology·Arif LuqmanFriedrich Götz

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Citations

Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Syed Ahmed ShahMubeen Kousar

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