PMID: 8947934Nov 1, 1996Paper

Reinforcement processes in opiate addiction: a homeostatic model

Neurochemical Research
G Schulteis, George F Koob

Abstract

The development of tolerance and dependence has traditionally been considered an integral aspect of the drug addiction process, and opiate dependence has been studied extensively as a model system in this regard. However, recent emphasis on the positive reinforcing properties of drugs has led to the suggestion that tolerance, dependence, and withdrawal may be of secondary or even negligible importance in motivating compulsive drug use. The current article argues for an integrated view of addiction in the form of a homeostatic neuroadaptation model which emphasizes the motivational significance of both the positive affective state produced by opiates and the negative affective state characteristic of drug withdrawal. The model is supported by evidence at both the behavioral and neural systems levels of analysis. Understanding the important distinction between somatic and affective components of opiate withdrawal is key to recognizing the factors which contribute to the motivational significance of opiate dependence and withdrawal. In addition, the critical role of conditioning processes in the maintenance of compulsive drug use and relapse after periods of abstention is discussed. Finally, it is argued that both the positive rei...Continue Reading

References

Jul 1, 1975·Journal of Comparative and Physiological Psychology·S Siegel
Oct 25, 1979·The New England Journal of Medicine·J H Mendelson, N K Mello
May 1, 1992·Trends in Neurosciences·G F KoobL Stinus
May 1, 1992·Trends in Pharmacological Sciences·G F Koob
May 1, 1992·Trends in Pharmacological Sciences·G Di Chiara, R A North
Jul 1, 1991·Psychological Review·C X Poulos, H Cappell
Jan 1, 1990·Psychopharmacology·M W Emmett-OglesbyH Lal
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·L Kokkinidis, B D McCarter
Jul 1, 1988·Trends in Neurosciences·A MansourS J Watson
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·G F KoobF E Bloom
Nov 4, 1988·Science·G F Koob, F E Bloom
Jan 1, 1988·Annals of the New York Academy of Sciences·G F Koob, N R Swerdlow
Jan 1, 1988·Psychopharmacology·T S ShippenbergA Herz
Jun 1, 1988·Pharmacology, Biochemistry, and Behavior·W A Corrigall, F J Vaccarino
Dec 1, 1986·Pharmacology, Biochemistry, and Behavior·G J Schaefer, R P Michael
Dec 1, 1985·Pharmacology, Biochemistry, and Behavior·K A ZitoD C Roberts
Feb 1, 1986·Archives of General Psychiatry·F H Gawin, H D Kleber
Jun 1, 1969·The Journal of Nervous and Mental Disease·C A Haertzen, N T Hooks
Aug 1, 1974·Psychological Medicine·J J Jacob, G M Michaud
Jan 1, 1974·AJS; American Journal of Sociology·W E McAuliffe, R A Gordon
Jan 1, 1973·Psychopharmacologia·B E Jones, J A Prada
Apr 1, 1974·European Journal of Pharmacology·D S KoserskyL S Harris
Jan 1, 1969·Psychopharmacologia·G DeneauM H Seevers
Mar 20, 1972·JAMA : the Journal of the American Medical Association
Oct 14, 1964·Psychopharmacologia·J R Weeks, R J Collins
Mar 1, 1984·Pharmacology, Biochemistry, and Behavior·N E GoedersJ E Smith

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Citations

Nov 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mirjam A F M GerritsJan M van Ree
Jul 16, 2003·European Journal of Pharmacology·Svetlana SemenovaAthina Markou
Mar 29, 2001·Pharmacology, Biochemistry, and Behavior·R A BevinsK S Pickett
Jul 25, 1998·Pharmacology, Biochemistry, and Behavior·G SchulteisG F Koob
Oct 13, 1998·Pharmacology, Biochemistry, and Behavior·L A Parker, A Joshi
Jan 1, 1997·Peptides·G A OlsonA J Kastin
Oct 17, 1998·Progress in Neurobiology·F Fadda, Z L Rossetti
Feb 22, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesco PapaleoAngelo Contarino
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·A KösterR K Reinscheid
Oct 30, 2001·Journal of Addictive Diseases·N S Miller, R J Goldsmith
Jan 5, 2006·ILAR Journal·Kimberlei A RichardsonGabrielle L McLemore
Feb 8, 2005·Psychopharmacology·Andrew C Harris, Jonathan C Gewirtz
Feb 19, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Qian HeZengzhen Wang
Mar 1, 2011·The Journal of Pain : Official Journal of the American Pain Society·Louis P Vera-PortocarreroFrank Porreca
Jan 20, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alicia CabralVanessa M Castilho
Nov 13, 2008·Pharmacology, Biochemistry, and Behavior·Melissa K Stephens, Anthony L Riley
Oct 29, 2008·Behavioural Brain Research·Sam G BuckmanShoshana Eitan
Jul 31, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Li-Tzy WuAshwin A Patkar
Jun 26, 2008·European Journal of Pharmacology·Milton A V AvilaVanessa M Castilho
Mar 1, 2008·Pharmacology, Biochemistry, and Behavior·Zhongqi Zhang, Gery Schulteis
Dec 7, 2007·Drug and Alcohol Dependence·Li-Tzy WuAshwin A Patkar
Sep 29, 2011·Journal of Neurochemistry·Qian-Qian LiLin Lu
Jun 10, 2010·Journal of Psychopharmacology·A ColasantiD J Nutt
Nov 27, 2009·Journal of Psychopharmacology·Stephen R HodgsonShoshana Eitan
Jul 13, 2000·Nature·G SchulteisB J Everitt
Jul 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zheng-Xiong XiShi-Jiang Li

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