Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis

Frontiers in Immunology
Susanta PahariJaved N Agrewala

Abstract

The mononuclear phagocyte system (MPS) constitutes dendritic cells, monocytes, and macrophages. This system contributes to various functions that are essential for maintaining homeostasis, activation of innate immunity, and bridging it with the adaptive immunity. Consequently, MPS is highly important in bolstering immunity against the pathogens. However, MPS is the frontline cells in destroying Mycobacterium tuberculosis (Mtb), yet the bacterium prefers to reside in the hostile environment of macrophages. Therefore, it may be very interesting to study the struggle between Mtb and MPS to understand the outcome of the disease. In an event when MPS predominates Mtb, the host remains protected. By contrast, the situation becomes devastating when the pathogen tames and tunes the host MPS, which ultimately culminates into tuberculosis (TB). Hence, it becomes extremely crucial to reinvigorate MPS functionality to overwhelm Mtb and eliminate it. In this article, we discuss the strategies to bolster the function of MPS by exploiting the molecules associated with the innate immunity and highlight the mechanisms involved to overcome the Mtb-induced suppression of host immunity. In future, such approaches may provide an insight to develop ...Continue Reading

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Citations

Apr 1, 2018·Biological Chemistry·Michelle Galeas-PenaDerek Pociask
Dec 5, 2018·World Journal of Gastroenterology : WJG·Yu YangPing Zhang
Jun 14, 2019·Frontiers in Microbiology·Shikha NegiJaved N Agrewala
Nov 22, 2019·Frontiers in Immunology·Shikha NegiJaved N Agrewala
Sep 23, 2020·The Journal of Infectious Diseases·Monika M LooneyMarc K Halushka

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Methods Mentioned

BETA
nuclear translocation
bronchoalveolar lavages
GTPases
GTPase
ubiquitination

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