PMID: 6411766Sep 1, 1983Paper

Reinitiation of sperm production in gonadotropin-suppressed normal men by administration of follicle-stimulating hormone

The Journal of Clinical Investigation
A M MatsumotoW J Bremner

Abstract

The specific roles of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in controlling human spermatogenesis are poorly understood. We studied the effect of an experimentally induced, selective LH deficiency on sperm production in normal men. After a 3-mo control period, five men received 200 mg testosterone enanthate (T) i.m./wk to suppress LH, FSH, and sperm counts. Then, while continuing T at the same dosage, human FSH (hFSH) was administered simultaneously to replace FSH activity, leaving LH activity suppressed. Four men received 100 IU hFSH s.c. daily plus T (high dosage hFSH) for 13-14 wk, while one man received 50 IU hFSH s.c. daily plus T (low dosage hFSH) for 5 mo. The effect on sperm production of the selective LH deficiency produced by hFSH plus T administration was assessed. In the four men who received the high dosage hFSH regimen, sperm counts were markedly suppressed during T administration alone (0.3+/-0.2 million/cm(3), mean+/-SE, compared with 94+/-12 million/cm(3) during the control period). Serum LH bioactivity (determined by in vitro mouse Leydig cell assay) was suppressd (140+/-7 ng/ml compared with 375+/-65 ng/ml during control period) and FSH levels (by radioimmunoassay) were reduced to und...Continue Reading

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Citations

Jul 20, 2007·Pituitary·Clement C Cheung, Robert H Lustig
Oct 1, 1989·Journal of Steroid Biochemistry·A M Matsumoto, W J Bremner
Apr 1, 1995·Trends in Endocrinology and Metabolism : TEM·R I McLachlanD M de Kretser
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·D M de KretserN G Wreford
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·C Wang, R S Swerdloff
Dec 12, 2012·Nature Reviews. Urology·Daniela ValentiAldo E Calogero
Apr 12, 2001·International Journal of Andrology·D Kinniburgh, R A Anderson
Apr 26, 2008·Endocrine Reviews·Stephanie T PageWilliam J Bremner
Oct 13, 2006·Journal of Endocrinological Investigation·V A Giagulli, D Carbone
Dec 15, 2004·International Journal of Andrology·Robert W Holdcraft, Robert E Braun
Mar 1, 1988·Risk Analysis : an Official Publication of the Society for Risk Analysis·M L Meistrich
Feb 1, 1987·Baillière's Clinical Endocrinology and Metabolism·A M Matsumoto, W J Bremner
Jan 1, 1984·Annals of the New York Academy of Sciences·H G Burger, H W Baker
Oct 4, 2008·Current Opinion in Urology·Carlo ForestaAlberto Ferlin
Apr 7, 2006·Human Reproduction Update·Kati L Matthiesson, Robert I McLachlan
Apr 20, 2006·The Journal of Clinical Endocrinology and Metabolism·Melanie J WaltonRichard A Anderson
Aug 10, 2006·The Journal of Clinical Endocrinology and Metabolism·Kati L MatthiessonSarah J Meachem
May 10, 2000·Journal of Endocrinological Investigation·A Gambineri, R Pasquali

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