PMID: 3758279Oct 1, 1986Paper

Reinnervation and recovery of cat muscle receptors after long-term denervation

Experimental Neurology
D BarkerM J Stacey

Abstract

After nerve injury muscles remain denervated until axons return to begin reinnervation and recovery. The delay between injury and recovery in human limb nerves averages 13 weeks after crush, and 16 weeks after transection and suture. In order to assess the effects of such long denervation periods on the recovery of cat muscle receptors, we crushed the common peroneal nerve and denervated peroneus brevis for 10 to 134 days; 39 days were allowed for reinnervation in each experiment. After 50 days denervation, the mean number of terminal bands in the regenerated spindle primary endings was 10.3 compared with a normal mean of 29.0. After 134 days, the mean was 0.6 and spindles were severely atrophied. Despite this most spindle afferent fibers continued to respond normally to ramp-and-hold stretch, abnormal responses being recognized as those that failed to maintain firing during the held phase of the ramp. After 50 days, 21% of spindle afferent fibers responded abnormally and about this proportion did so after all the longer denervation periods. Maximum afferent firing rates were all significantly lower than normal, and many afferent fibers fatigued more rapidly. Tendon organs were atrophied after 113 and 134 days and received fewe...Continue Reading

References

Nov 4, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R W BanksM J Stacey

❮ Previous
Next ❯

Citations

Jan 1, 1995·Microsurgery·N KostakogluC J Green
Jan 1, 1990·British Journal of Plastic Surgery·D BarkerJ J Scott
Apr 1, 1994·Pharmacology & Therapeutics·D N IshiiS F Pu
Jan 1, 1995·Brain Research. Brain Research Reviews·D N Ishii
Jan 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A PatakJ E Gregory
Aug 27, 1993·Annals of the New York Academy of Sciences·D N IshiiL R Whalen
May 15, 2007·The Journal of Physiology·Gee Hee KimKenro Kanda
May 5, 2006·Journal of Neurophysiology·Milana P MileusnicGerald E Loeb
Jul 27, 2011·The Journal of Physiology·Jonathan F PratherTimothy C Cope
Dec 1, 1989·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S Grundfest-BroniatowskiH M Tucker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand
R W BanksH G Brown
International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
J E Gregory, U Proske
© 2021 Meta ULC. All rights reserved