PMID: 6148258Oct 1, 1984Paper

Reinnervation of normal and dystrophic skeletal muscle

Experimental Neurology
S P Yeagle, E X Albuquerque

Abstract

A comparative study was conducted of resting membrane potential (RMP), extrajunctional acetylcholine (ACh) sensitivity, spontaneous and neurally evoked transmitter release, and directly and indirectly elicited action potentials in posterior latissimus dorsi (PLD) muscles of normal (line 412) and dystrophic (line 413) chickens during reinnervation after nerve crush. Control (nondenervated) dystrophic muscle fibers had a significantly greater RMP (-77.2 vs. -74.1 mV), extrajunctional ACh sensitivity (0.34 vs. 0.04 mV/nC), and incidence of repetitive firing of directly elicited action potentials than did normals. Miniature end-plate potential (MEPP) amplitude in dystrophic fibers was significantly reduced (0.26 vs. 0.38 mV). Six to 7 days after nerve crush, muscle fibers from both lines of chickens showed a significant reduction in RMP and an increase in extrajunctional ACh sensitivity. During this time spontaneous MEPPs were absent and the incidence of repetitive firing was decreased. No significant difference was noted between chicken lines in any of the properties studied. The return of normal properties associated with reinnervation occurred primarily between days 9 and 40. Repolarization of the RMP was clearly evident by day ...Continue Reading

Related Concepts

Acetylcholine Sulfate (1: 1)
Electrophysiology (Science)
Potentials, Event-Related
Resting Potentials
Motor Endplate
Muscle
Muscular Dystrophy, Animal
Nerve Crush
Nerve Regeneration
Neurohormones

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