Apr 11, 2020

Environmental enrichment alleviates the deleterious effects of stress in experimental autoimmune encephalomyelitis

BioRxiv : the Preprint Server for Biology
A. P. FournierFabian Docagne

Abstract

Clinical observations support the hypothesis that stressful events increase relapse occurrence in multiple sclerosis patients, while stress-reduction strategies can modulate this effect. However, a direct cause-effect relationship between stress level and relapse cannot be firmly established from these data. The purpose of this work was to address whether modulation of stress could interfere with symptom relapse in an animal model of multiple sclerosis with relapsing-remitting course. We report that repeated acute stress induced a twofold increase in relapse incidence in experimental autoimmune encephalomyelitis. On the other hand, environmental enrichment reduced relapse incidence and severity, and reversed the effects of repeated acute stress. These data provide the platform for further studies on the biological processes that link stress and multiple sclerosis relapses in a suitable animal model.

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Mentioned in this Paper

Study
Decision Making
Memory, Episodic
Psychological Reinforcement
Experience
FMRI
Clinical Trials
Memory
Sampling - Surgical Action
Cardiac Ablation

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