Reintroduction of continuous negative pressure ventilation in neonates: two-year experience

Pediatric Pulmonology
W G CvetnicL Gluck


Continuous negative pressure ventilation utilizes subatmospheric pressure around the thorax to improve oxygenation. It has not been routinely used since the mid-1970s. We treated 37 infants with the combination of continuous negative pressure (CNP) and intermittent mandatory ventilation (IMV), after failing to attain a PaO2 of greater than or equal to 50 torr on IMV alone. Lung diseases included pulmonary interstitial emphysema (PIE), respiratory distress syndrome (RDS), and pulmonary artery hypertension (PAH) due either to meconium aspiration syndrome (MAS) or other causes (non-MAS). All infants had evidence of severe parenchymal pulmonary disease, or pulmonary artery hypertension resulting in persistent hypoxemia and hypotension. In the PIE group, CNP was started later in the course of the disease, and both positive pressure and oxygen were maintained for a longer period. The group of infants with non-MAS PAH required CNP and positive pressure ventilation for the shortest period of time. The infants with PIE also had a greater incidence of bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH). In addition, three patients with PIE died. In the non-MAS patients with PAH, no complications and no deaths occurred....Continue Reading


May 1, 1973·Pediatric Clinics of North America·V Chernick
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Feb 1, 1970·The Journal of Pediatrics·M T StahlmanJ Gray
Aug 1, 1970·The Journal of Pediatrics·A N Krauss, P A Auld

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Apr 30, 1994·Early Human Development·K PalmerP Rolfe
Jul 8, 1998·Pediatric Clinics of North America·M C McGettiganJ P Goldsmith
Jan 29, 2005·Pediatric Pulmonology·Thomas L MillerMarla R Wolfson

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