PMID: 8960507Nov 1, 1996Paper

Reirradiation tolerance of the rat heart

International Journal of Radiation Oncology, Biology, Physics
J WondergemE G Strootman

Abstract

To investigate the influence of reirradiation on the tolerance of the heart after a previous irradiation treatment. Female Wistar rats were locally irradiated to the thorax. Development of cardiac function loss was studied with the ex vivo working rat heart preparation (20). To compare the retreatment experiments, initial, and reirradiation doses were expressed as the percentage of the extrapolated tolerance dose (ETD) (1). Local heart irradiation with a single dose led to a dose-dependent and progressive decrease in cardiac function. The progressive nature of irradiation-induced heart disease is shown to affect the outcome of the retreatment, depending on both the time interval between subsequent doses and the size of the initial dose. The present data demonstrate that hearts are capable of repairing a large part of the initial dose of 10 Gy within the first 24 h. However, once biological damage as a result of the first treatment is fixed, the heart does not show any long-term recovery. At intervals up to 6 months between an initial treatment with 10 Gy and subsequent reirradiation, the reirradiation tolerance dose slightly decreased from 74% of the ETDref (at 24-h interval) to 68% of the ETDref (at 6-month interval). Between ...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·N A FrankenJ Wondergem
Apr 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A C RuifrokA J van der Kogel
Jan 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S Schultz-HectorH D Thames
Jun 1, 1990·International Journal of Radiation Oncology, Biology, Physics·F A StewartA Luts
May 1, 1988·International Journal of Radiation Oncology, Biology, Physics·N H TerryE L Travis
Nov 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J Wondergem, J Haveman
Jun 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·T K Yeung, J W Hopewell
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·G W Barendsen

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Citations

Jan 7, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J WondergemJ Broerse
Nov 1, 1996·International Journal of Radiation Oncology, Biology, Physics·K R Trott
Aug 3, 2012·Journal of the American Veterinary Medical Association·Nicholas J RancilioElizabeth A McNiel
Mar 11, 2011·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·David A BommaritoJimmy C Lattimer
Aug 18, 2004·Journal of Molecular Biology·Michael J McGuireKathlynn C Brown
Sep 8, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·S Armstrong, P Hoskin

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