PMID: 7014153Mar 20, 1981Paper

Rejected human corneal grafts. I. Clinical study

Documenta Ophthalmologica. Advances in Ophthalmology
C C Kok-van AlphenG Vrensen

Abstract

As introduction to a light- and electron-microscopial examination of rejected human corneal grafts a summary is given of the clinical signs of rejection. It is extremely important to recognize these signs in time and to initiate the correct therapy. Most failures in corneal transplantation are due to rejection. Rejection reactions are often not recognized early enough. The differential diagnosis is difficult because so many factors can trigger off a rejection. As the diagnosis is so often missed it is a good thing to consider the clinical picture of graft rejection once more. Maumenee: 'most ophthalmologists do not recognize the signs of early graft failure and usually do not refer the patient back for therapy until considerable oedema has developed from endothelial destruction' (1962). In the cases with a good prognosis the rejection percentage is plus or minus 12%; in vascularized corneas and complicated corneal transplantations as high as 75% (Polack, 1977).

References

Apr 1, 1974·American Journal of Ophthalmology·J W Chandler, H E Kaufman
May 1, 1951·American Journal of Ophthalmology·A E MAUMENEE

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Citations

Jun 15, 1991·American Journal of Ophthalmology·D C MuschR F Meyer
Sep 10, 2002·Transplant Immunology·Benjamin A Bradley

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