PMID: 8581414Sep 1, 1995Paper

Rejection of cartilage formed by transplanted allogeneic chondrocytes: evaluation with monoclonal antibodies

Transplant Immunology
A RomaniukStanislaw Moskalewski

Abstract

Cellular infiltrates participating in rejection of cartilage formed by transplanted allogeneic rat epiphyseal chondrocytes were evaluated immunohistochemically using a panel of different monoclonal antibodies. One week after transplantation, the grafts were surrounded by numerous class II MHC+ (OX6+, OX17+), CD4+ (W3/25+), and W3/13+ cells as well as some ED1+ monocytes/macrophages. Only a few T (OX19+) and B (HIS14+) cells were present. The number of class II MHC+ cells and ED1+ monocytes/macrophages did not change significantly in the course of rejection whereas the number of CD4+ and W3/13+ cells gradually decreased. On the other hand, there was a significant increase in the number of CD8+ (OX8+) cells. CD8+ cells accumulated close to the transplants and some of them penetrated cartilage matrix suggesting that they might be involved in chondrocyte killing. After 3 months, cartilage was almost completely destroyed and the intensity of infiltrations was markedly decreased. Fibrous connective tissue predominated, however, some class II+ as well as few ED1+, CD4+ and CD8+ cells were still present adjacent to the cartilage remnants. At the time of transplantation, chondrocytes were endowed with RT1.D class II antigen (OX17+), but...Continue Reading

References

Jun 1, 1979·European Journal of Immunology·W R McMaster, A F Williams
Jan 1, 1979·Cell and Tissue Research·J Thyberg, S Moskalewski
Oct 1, 1978·Annals of the Rheumatic Diseases·G BentleyR Mukerjhee
Jan 1, 1990·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·J BujiaE Kastenbauer
Dec 30, 1986·Biochemical and Biophysical Research Communications·F OllivierreB V Treadwell
Jul 1, 1985·The Journal of Experimental Medicine·W A JefferiesA F Williams
Oct 1, 1986·Scandinavian Journal of Immunology·G HedlundH O Sjögren
Jan 1, 1985·Archives of Oto-rhino-laryngology·S Bator
Sep 21, 1968·Nature·A Maroudas, P Bullough
Jan 1, 1983·Immunological Reviews·D W MasonM L Thomas
Jan 1, 1994·Acta Oto-laryngologica·J BujíaG Burmester

❮ Previous
Next ❯

Citations

Dec 10, 2008·Tissue Engineering. Part B, Reviews·Christopher M Revell, Kyriacos A Athanasiou
Oct 21, 2015·Immunologic Research·Benjamin SmithDaniel A Grande
Jun 10, 2009·Cellular Immunology·Agata BiałoszewskaJacek Malejczyk
Jun 2, 2015·Acta Biomaterialia·B ArziK A Athanasiou
May 23, 2008·Cellular Immunology·Wonil OhJae Kwon Lee
Jul 12, 2002·Microscopy Research and Technique·Stanisław MoskalewskiAnna Osiecka-Iwan
Mar 4, 2000·Cell Transplantation·A Osiecka-IwanS Moskalewski
Dec 5, 2018·Npj Regenerative Medicine·A LongoniD Gawlitta
Jul 1, 2013·Cartilage·Francesca VanniniSandro Giannini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.