Rejection with hemodynamic compromise: objective evidence for efficacy of photopheresis

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
J K KirklinM Marques

Abstract

Photopheresis therapy (photo) has been advocated as a therapy to improve outcome after recalcitrant or severe rejection, but objective evidence of a beneficial effect has been elusive. This study examined the hypothesis that photo provides protection against rejection, rejection with hemodynamic compromise (HC), and death from rejection after cardiac transplantation. Between 1990 and 2003, 36 adult patients (from 343 adult transplant recipients) received at least 3 months of photo (2-day treatment every 3 to 6 weeks for a target of 18 months) after HC rejection (n = 12), recurrent/recalcitrant rejection (n = 20), or as prophylaxis in the presence of anti-donor antibodies (n = 4). Survival and risk factors were examined by analysis using multivariate hazard function modulated renewal function. Patients selected for photo were at greater risk for rejection (p < 0.0001) and HC rejection (p < 0.0001) than non-photo patients. After 3 months of photo therapy, rejection risk was decreased (p = 0.04). More importantly, the hazard for subsequent HC rejection or rejection death was significantly reduced toward the risk-adjusted level of lower-risk non-photo patients (p = 0.006). This study provides objective evidence that photo reduces t...Continue Reading

References

Nov 1, 1995·The Journal of Experimental Medicine·B VerhovenP Williamson
Mar 21, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·E PahlUNKNOWN Pediatric Heart Transplant Study
Oct 23, 2002·The Journal of Experimental Medicine·Kang LiuRalph M Steinman
Jan 18, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Paul J MichaelsMichael C Fishbein
Sep 6, 2003·Journal of Cutaneous Medicine and Surgery·Mark L Barr

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Citations

Sep 16, 2010·Current Treatment Options in Cardiovascular Medicine·Claire A Irving, Steven A Webber
Jun 1, 2012·Current Treatment Options in Cardiovascular Medicine·Michelle M Kittleson
Feb 5, 2014·Immunotherapy·David H ChangJon A Kobashigawa
Oct 15, 2014·Immunotherapy·Markus J Barten, Maja-Theresa Dieterlen
Sep 25, 2015·Expert Review of Cardiovascular Therapy·David H Chang, Jon A Kobashigawa
Apr 9, 2010·Expert Opinion on Biological Therapy·Alice F Li, Alan Escher
Mar 7, 2009·Expert Opinion on Emerging Drugs·Kiran K Khush, Hannah A Valantine
Nov 30, 2013·Cardiology Clinics·Michelle M Kittleson, Jon A Kobashigawa
Jan 24, 2016·Journal of Clinical Apheresis·Steven A MannJill Adamski
Feb 9, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon KobashigawaUNKNOWN Consensus Conference Participants
Nov 5, 2010·The Journal of Thoracic and Cardiovascular Surgery·John M KaramichalisMax B Mitchell
Oct 7, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Josef StehlikUNKNOWN Cardiac Transplant Research Database Group
Aug 12, 2009·Journal of the American Academy of Dermatology·Robert KnoblerHildegard Greinix
May 5, 2009·Transplant Immunology·Mikaël HivelinLaurent Lantieri
Apr 1, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·François HaddadSharon Hunt
May 28, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James F GeorgeJames K Kirklin
Nov 21, 2007·Critical Care Nursing Clinics of North America·Deborah G Klein
Mar 31, 2007·Journal of Clinical Apheresis·Zbigniew M SzczepiorkowskiUNKNOWN Apheresis Applications Committee of the American Society for Apheresis
Jul 7, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W E UberN L Pereira
Jun 8, 2011·Journal of Clinical Apheresis·Marisa B Marques, Joseph Schwartz
Sep 8, 2011·Journal of Clinical Apheresis·David M Ward
Jun 23, 2010·Journal of Clinical Apheresis·Zbigniew M SzczepiorkowskiUNKNOWN Apheresis Applications Committee of the American Society for Apheresis
Dec 21, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·R KnoblerU Hillen
May 16, 2014·Journal of Clinical Apheresis·Marisa B Marques, Jill Adamski
Dec 18, 2013·Clinical and Experimental Immunology·M-T DieterlenM J Barten
Sep 2, 2010·Journal of Clinical Apheresis·Rasheed A BalogunEmaad M Abdel-Rahman
Mar 26, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Waldemar F CarloJames K Kirklin
May 10, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Guillaume CoutanceShaida Varnous
Apr 26, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Cesare Perotti, Irena Sniecinski
Mar 10, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jignesh PatelJon A Kobashigawa
Aug 16, 2008·Journal of the American College of Cardiology·Sharon A Hunt, François Haddad
Mar 9, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jeffrey G GossettUNKNOWN Pediatric Heart Transplant Study Investigators
Apr 29, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Peter Jaksch, Robert Knobler
Aug 4, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Franz TrautingerRobert Knobler
Jun 21, 2016·Journal of Clinical Apheresis
Aug 28, 2014·Current Opinion in Organ Transplantation·Michelle M Kittleson, Jon A Kobashigawa
Nov 12, 2016·World Journal for Pediatric & Congenital Heart Surgery·James K KirklinF Bennett Pearce
Apr 4, 2015·Circulation·Monica M ColvinUNKNOWN American Heart Association Heart Failure and Transplantation Committee of the Council on Cardiovascular Surgery and Anesthes
Apr 12, 2019·Current Opinion in Organ Transplantation·Yogesh N V Reddy, Naveen L Pereira
Feb 8, 2007·Current Opinion in Cardiology·Michael Chan, Glen J Pearson
Sep 14, 2018·Frontiers in Medicine·Ara ChoRobert Knobler
May 16, 2019·Current Opinion in Organ Transplantation·Yogesh N V Reddy, Naveen L Pereira
Aug 15, 2012·Current Opinion in Organ Transplantation·Michelle M Kittleson, Jon A Kobashigawa

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