PMID: 9535663May 2, 1998Paper

Rejoining of DNA by the RAG1 and RAG2 proteins

Science
M MelekD C van Gent

Abstract

Assembly of immunoglobulin and T cell receptor genes from separate gene segments [V(D)J recombination] begins with DNA double-strand breakage by the RAG1 and RAG2 proteins, acting at a pair of recombination signal sequences (RSSs). Here, the RAG proteins are shown to reverse the cleavage reaction by joining an RSS to a broken coding sequence end. These "hybrid joints" have also been found in lymphoid cells, even when the normal pathway of DNA double-strand break repair is inactive, and can now be explained by this activity of the RAG proteins.

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Citations

Mar 3, 2001·Current Opinion in Immunology·U Grawunder, E Harfst
Apr 20, 2006·Nature Structural & Molecular Biology·J Jefferson P PerryJohn A Tainer
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