Rejuvenation of ribosomal RNA gene repeats at the nuclear pore

Current Genetics
Chihiro Horigome, Takehiko Kobayashi

Abstract

The ribosomal RNA genes (rDNA) exist as tandem repeats in eukaryotes and are, therefore, highly unstable. Each rDNA unit includes a replication fork barrier site to avoid collisions between DNA replication forks and transcriptional machinery. However, because of this barrier, DNA double-strand breaks are induced at a relatively high frequency. If damage is repaired by the homologous recombination in rDNAs, it may result in frequent copy number changes and the production of extrachromosomal ribosomal DNA circles, both of which are closely linked to the regulation of lifespan. Here, we review recent progress in elucidating a multi-layered repair process of rDNA that occurs in the nucleolus, nucleoplasm and nuclear pores. Binding to nuclear pores appears to be the final strategy for repairing any remaining damage to the rDNA. Here, we propose the possible contribution of nuclear pores to the asymmetric distribution of damaged rDNA between mother and daughter cells as well as its possible impact on aging/rejuvenation.

References

Dec 1, 1994·The Journal of Cell Biology·B K KennedyL Guarente
Jan 15, 1998·Cell·D A Sinclair, L Guarente
Nov 5, 1999·Trends in Biochemical Sciences·J R Warner
Jun 5, 2003·Genes & Development·Yasushi TakeuchiTakehiko Kobayashi
Jan 1, 1950·Journal of General Microbiology·A A BARTON
Sep 6, 2005·Science·Takehiko Kobayashi, Austen R D Ganley
Jun 12, 2009·Nature·Weiwei DangShelley L Berger
Feb 6, 2010·Science·Satoru IdeTakehiko Kobayashi
May 29, 2013·Molecular Systems Biology·Tharan SrikumarBrian Raught
Feb 4, 2014·FEMS Microbiology Reviews·Annina Denoth LippunerYves Barral
Oct 27, 2015·Nature Cell Biology·Taehyun RyuIrene Chiolo
Aug 4, 2016·Cell Cycle·Chihiro Horigome, Susan M Gasser
Oct 8, 2016·Small·Myeong Chan Jo, Lidong Qin
Jan 21, 2017·Trends in Genetics : TIG·Nuno AmaralIrene Chiolo
Sep 1, 2017·Nature Communications·Abigail Buchwalter, Martin W Hetzer
Oct 26, 2018·Nature Reviews. Genetics·Abigail BuchwalterMartin W Hetzer
Jan 8, 2019·Molecular Cell·Tetsushi Iida, Takehiko Kobayashi

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Methods Mentioned

BETA
electrophoresis

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