Relapse after short-course chemotherapy of patients with sputum smear-positive pulmonary tuberculosis under routine conditions with additional information on side effects and contact tracing

Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
F D Martinez, H M Hernandez

Abstract

The region of Leon/Chinandega in Western Nicaragua. To assess the relapse rate after short course chemotherapy with thioacetazone in the continuation phase in patients with sputum smear-positive pulmonary tuberculosis. A cohort of 247 new sputum smear-positive patients with pulmonary tuberculosis, started on the national short-course treatment (2SRHZ/6TH) between October 1986 and April 1988 as part of the National Tuberculosis Programme, were followed up for 17-32 months after completion of treatment. Two thirds of the patients spent the first 2 months hospitalized, the rest received the whole treatment as out-patients. 204 (83%) completed treatment, seven failure cases were cured with retreatment, 24 defaulted, 10 were transferred out and two died. The patients who completed treatment continued to undergo smear examination for acid-fast bacilli every three months. Of the 204 patients who completed treatment, five died and 10 were lost to follow-up. The remaining 189 patients were followed up for a total of 388 person-years. Three relapses appeared (1.6%), one relapse during 129 person years of observation. Two of the relapse cases were hospitalized, and the third received the full treatment as an out-patient. In the 223 patien...Continue Reading

Citations

Dec 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marie-Laurence LambertPatrick Van der Stuyft

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