Relapse and Mortality Risk of Stage I Testicular Cancer

Journal of Insurance Medicine
Cecilia FlorvallGedske Daugaard

Abstract

- To assess the medical insurance risk for patients with stage I testicular cancer (TC), by calculating the overall mortality risk with and without relapse, and compare it to men from the Danish population. - Testicular cancer is the most common malignancy in young males. Outcomes of a Danish cohort of 3366 patients with stage I TC (1366 non-seminomas (NSTC) and 2000 Seminomas (STC)), were analyzed. - The data were analyzed by the "illness-death" model. For the analysis of the transitions between diagnosis, relapse and death we adopted a parametric approach, where the relationship between the intensities and the effect of covariates were specified by Poisson regression models for NSTC and STC individually. - In the NSTC group, 422 patients relapsed. Six relapses (1.4%) occurred after 5 years of follow-up. In the STC group, 389 relapsed. The relapse rate after 5 years was 4.1%. The overall mortality analyses showed that the standardized mortality ratio (SMR) for men with NSTC without relapse, was slightly lower than in the matched general population of Danish men (SMR = 0.9). In STC patients without relapse, SMR was 0.80. Relapse raised the overall mortality by a factor 2.0 for NSTC and 1.5 for STC. - The fact that few relapses ...Continue Reading

References

Aug 4, 2011·Scandinavian Journal of Public Health·Karin Helweg-Larsen
Aug 4, 2011·Scandinavian Journal of Public Health·Elsebeth LyngeMatejka Rebolj
Jul 30, 2014·European Urology·Mette Saksø MortensenGedske Daugaard
Oct 1, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gedske DaugaardJakob Lauritsen
Nov 9, 2016·Clinical Epidemiology·Gedske DaugaardJakob Lauritsen

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Citations

Mar 10, 2021·Nature Reviews. Urology·Michal ChovanecGedske Daugaard

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