Relapse in psoriasis with two different tapering regimens of methotrexate: a randomized open-label controlled study

Indian Journal of Dermatology, Venereology and Leprology
Satyendra Kumar Singh, Tulika Rai

Abstract

Background : Systemic therapy with methotrexate is a very useful modality in psoriasis, but relapses can occur soon after stopping it. Aim : To compare the relapse rates in psoriasis with two different tapering regimens of methotrexate after control is achieved. Methods : This was a randomized open-label controlled study, and patients of chronic plaque psoriasis with psoriasis area and severity index (PASI) >10 were included. Methotrexate 0.3 mg/kg weekly was given and the PASI calculated every 2 weeks. After achieving a 75% reduction in the PASI (PASI-75), patients were assigned randomly in to one of three groups. In the half-dose group, the dose of methotrexate was reduced to half and given weekly; in the 2-weekly group, the same dose was given at 2-week intervals; in the control group, methotrexate was stopped. Patients were followed up for 12 weeks. Results : Out of 141 registered patients, 81 were included: 27 in the half-dose group, 28 in the 2-weekly group, and 26 in the control group. After further exclusions due to adverse effects and loss to follow-up, the results were analysed for 16, 17 and 19 patients respectively in the 3 groups. There was statistically a highly significant difference in relapse rates between the ...Continue Reading

References

Jan 1, 1978·Dermatologica·T Fredriksson, U Pettersson
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Citations

Dec 8, 2015·Expert Opinion on Pharmacotherapy·Abraham M KormanSteven R Feldman
Apr 20, 2017·Journal of Immunoassay & Immunochemistry·Haseeb Ahsan
Nov 4, 2020·Dermatologic Therapy·Ali Sadeghinia, Maryam Daneshpazhooh
Apr 20, 2021·Indian Journal of Dermatology, Venereology and Leprology·Kaushal K VermaM Kalaivani
Oct 21, 2021·Indian Dermatology Online Journal·Murlidhar RajagopalanSushil Tahiliani

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