PMID: 7034164Jan 1, 1981Paper

Relapse of duodenal ulcer after treatment with trimipramine/antacids or cimetidine/antacids

Scandinavian Journal of Gastroenterology
A BerstadE Carlsen

Abstract

Ninety-three patients with duodenal ulcer were treated with trimipramine, 25 mg at night; cimetidine, 400 mg at night; or cimetidine, 1000 mg/day. In addition, all patients were given 20 ml antacids 1 and 3 h after meals. The healing rates after 6 weeks' treatment were 86%, 85%, and 100% in the three groups, respectively (differences not significant). After healing of the ulcers 88 of the patients were checked monthly during 1 year to study relapse rate. Endoscopy was performed on recurrence of symptoms suggesting relapse and after 6 and 12 months in all asymptomatic patients. Relapse was diagnosed in 64% of the patients in the trimipramine-treated group, in 48% in the 400 mg cimetidine group, and in 54% in th 1000 mg cimetidine group (differences not significant). The results suggest that ulcer recurrence is not commoner after treatment with standard dose of cimetidine than after a low dosage of cimetidine or trimipramine.

References

Apr 23, 1977·Lancet·K D BardhamA Walan
Nov 25, 1978·Lancet·J M CargillK G Wormsley
Jan 1, 1978·Scandinavian Journal of Gastroenterology·K ValnesT Qvigstad
Jan 1, 1979·Scandinavian Journal of Gastroenterology·A BerstadA Kruse-Jensen
May 18, 1979·Deutsche medizinische Wochenschrift·A SonnenbergA L Blum
Jan 1, 1981·Scandinavian Journal of Gastroenterology·M StrömA Walan

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Citations

Mar 1, 1995·Journal of Gastroenterology and Hepatology·G S Baldwin
Aug 30, 1985·The American Journal of Medicine·A L Blum
Mar 1, 1987·Scandinavian Journal of Gastroenterology·R Jorde, P G Burhol
Sep 1, 1987·Scandinavian Journal of Gastroenterology·B HallerbäckL Wählby
Jun 1, 1988·Scandinavian Journal of Gastroenterology·A MalesciG Ronchi
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·E Amdrup

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