Relapse of tardive dyskinesia due to reduction in clozapine dose

Indian Journal of Pharmacology
Meena ShrivastavaPravir Waradkar

Abstract

Clozapine is a second-generation (atypical) antipsychotic agent, which has been proven efficient against the positive and negative symptoms of schizophrenia, with a low propensity to induce tardive dyskinesia (TD). Compared with typical antipsychotics, it has a greater affinity for dopamine D4 than D2 receptors and additional action on serotonin 5-HT(2A) receptors. Due to its weak D(2) blocking action, it produces few extra pyramidal side effects and TD is rare. TD is one of the muscular side effects of antipsychotic drugs, especially the older generation like haloperidol. TD does not occur until after many months or years of taking antipsychotic drugs. TD is primarily characterized by abnormal involuntary movements of the tongue, lips or jaw, as well as facial grimacing or extremities that develop in association with the use of antipsychotic medications. TD can be embarrassing to the affected patient in public. The movements disappear during sleep and women are at greater risk than men for developing TD.

References

Nov 20, 2001·International Clinical Psychopharmacology·O UzunA Ozsahin
May 4, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Aygun Ertugrul, Basaran Demir

Citations

Apr 2, 2011·Indian Journal of Pharmacology·Samir Kumar Praharaj
Dec 7, 2013·Asian Journal of Psychiatry·Nandita HazariSandeep Grover

Methods Mentioned

BETA
sedation

Related Concepts

Clozapine
Limb Structure
Haloperidol
Jaw
Male Population Group
Schizophrenia
Sleep
Tongue Diseases
Antipsychotic Agents
Woman

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