Relapse rate of duodenal ulcer after cessation of long-term cimetidine treatment: a double-blind controlled study

Digestive Diseases and Sciences
M G KormanG Don

Abstract

Patients with a healed duodenal ulcer and who were symptom-free following 12 months of maintenance treatment with cimetidine 400 mg twice daily were randomized double-blind to a further 6 months therapy with either cimetidine 400 mg twice daily or placebo 2 tablets twice daily. Twenty-six patients received placebo and 15 patients cimetidine. Relapse was defined as symptoms for 3 out of 7 consecutive days and ulcer recurrence was confirmed by independent endoscopy. One of 15 patients on cimetidine relapsed: 20 of 26 patients on placebo relapsed. This relapse rate (77%) is similar to that found in previous studies after only 6 weeks cimetidine therapy (71%). This study suggests that 12 months cimetidine does not change the tendency of duodenal ulcer to recur and that the relapse rate is no greater than after 6 weeks cimetidine.

References

Apr 23, 1977·Lancet·K D BardhamA Walan
Mar 25, 1978·Lancet·W S BlackwoodT C Northfield
Nov 25, 1978·Lancet·J M CargillK G Wormsley
Apr 29, 1978·British Medical Journal·E Gudmand-HøyerH R Wulff
Jun 1, 1979·Digestive Diseases and Sciences·J Hansky, M G Korman
Oct 1, 1977·British Medical Journal·W A WallaceA R Bearn

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Citations

Feb 1, 1986·Digestive Diseases and Sciences·J E McGuiganE Z Dajani
Aug 1, 1982·Digestive Diseases and Sciences·M G KormanG T Schmidt
Jan 1, 1984·Pharmacology & Therapeutics·R E Pounder
Feb 1, 1996·Journal of Gastroenterology and Hepatology·S PanS H Chen
May 1, 1987·Scandinavian Journal of Gastroenterology·A WalanM Delattre
Sep 28, 1987·The American Journal of Medicine·M RodrigoJ L Segu
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·J P Miller
Jun 1, 1985·Australian and New Zealand Journal of Medicine·A J McLeanF J Dudley
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·M G Korman
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·J P Miller, E B Faragher
Oct 1, 1987·Postgraduate Medicine·G Zuckerman
Jan 1, 1987·Acta Medica Scandinavica·U BeckerP J Ranløv
Dec 1, 1986·British Journal of Clinical Pharmacology·P J PrichardW J Louis
Mar 1, 1991·Postgraduate Medicine·G GilbertE Thomas
Jan 1, 1993·Alimentary Pharmacology & Therapeutics·G DobrillaS Amplatz
Apr 1, 1987·Alimentary Pharmacology & Therapeutics·K Lauritsen, J Rask-Madsen
Jun 1, 1987·Drug Intelligence & Clinical Pharmacy·R R BerardiT T Nostrant
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·F I Lee

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