Relapse Versus Reinfection of Recurrent Tuberculosis Patients in a National Tuberculosis Specialized Hospital in Beijing, China

Frontiers in Microbiology
Zhaojing ZongYu Pang

Abstract

Tuberculosis (TB) recurrence can result from either relapse of an original infection or exogenous reinfection with a new strain of Mycobacterium tuberculosis (MTB). The aim of this study was to assess the roles of relapse and reinfection among recurrent TB cases characterized by a high prevalence rate of drug-resistant TB within a hospital setting. After 58 paired recurrent TB cases were genotyped to distinguish relapse from reinfection, 37 (63.8%) were demonstrated to be relapse cases, while the remaining 21 were classified as reinfection cases. Statistical analysis revealed that male gender was a risk factor for TB reinfection, odds ratios and 95% confidence interval (OR [95% CI]: 4.188[1.012-17.392], P = 0.049). Of MTB isolates obtained from the 37 relapse cases, 11 exhibited conversion from susceptible to resistance to at least one antibiotic, with the most frequent emergence of drug resistance observed to be levofloxacin. For reinfection cases, reemergence of rifampicin-resistant isolates harboring double gene mutations, of codon 531 of rpoB and codon 306 of embB, were observed. In conclusion, our data demonstrate that relapse is a major mechanism leading to TB recurrence in Beijing Chest Hospital, a national hospital spec...Continue Reading

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Citations

Nov 14, 2019·Infectious Diseases·Mohammed Saif AnaamAdel H Aldhubhani
Jul 17, 2020·Infectious Diseases·Yi LiuChuan You Li
Mar 6, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Prince AsareDorothy Yeboah-Manu
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Yan ShaoCheng Chen
Jul 1, 2021·Pharmacogenomics and Personalized Medicine·Edhyana SahiratmadjaIda Parwati
Aug 1, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yan LinGrania Brigden
Aug 10, 2021·Frontiers in Public Health·Prince AsareDorothy Yeboah-Manu
Dec 27, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Beibei QiuJianming Wang

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Methods Mentioned

BETA
genotyping
PCR
electrophoresis

Software Mentioned

Quantity One
SPSS

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