Relapses of optic pathway tumors after first-line chemotherapy

Pediatric Blood & Cancer
Valérie de HaasChantal Kalifa

Abstract

Chemotherapy is accepted as first-line conservative treatment of optic pathway tumors in patients younger than 5. Limited data are available on the outcome of patients with recurrence/progression after initial chemotherapy. Data on 68 children with Optic Pathway Tumors (OPT) treated with first-line Baby Brain (BBSFOP) chemotherapy at the Gustave Roussy Institute in Villejuif between 1990 and 2005 were reviewed. During a median follow-up of 6 years, 44 (65%) patients were diagnosed with one or more relapses. Most of the relapses occurred during the first 6 years of life. Overall and progression-free survival rates at 5 years after first relapse were 64% and 14%, respectively. First relapse was treated with chemotherapy, radiotherapy or surgery in 28, 9, and 6 patients, respectively. Best response to second-line chemotherapy was partial response in 10, stable disease in 10, and progressive disease in 8 patients. Patients with objective radiologic response to first-line chemotherapy, had a greater chance to respond again to second-line chemotherapy (RR = 90% vs. 15%, P = 0.003). Median time to progression after first relapse was 1.7, 2.5, and 3.1 years after surgery, chemotherapy and radiotherapy, respectively. Finally, 25 (37%) p...Continue Reading

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Citations

Oct 30, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·G BlanchardL Lion Francois
May 23, 2012·International Journal of Radiation Oncology, Biology, Physics·Richard M AwdehThomas E Merchant
Jul 22, 2009·Pediatric Blood & Cancer·Gary NicolinEric Bouffet
Mar 7, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric BouffetSylvain Baruchel
Nov 25, 2020·Neuro-Chirurgie·Irene StellaOlivier Klein

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