PMID: 6411408Sep 1, 1983Paper

Relapsing Neisseria meningitidis infection associated with C8 deficiency

Clinical Pediatrics
T E Liston

Abstract

Infection due to serogroup Y of Neisseria meningitidis has many clinical manifestations, ranging from mild bacteremia to fatal sepsis and meningitis. N. meningitidis infection may coincide with several complement deficiencies. A child is described who suffered from recurrent disease due to N. meningitidis, group Y, attributed to deficiency of the eighth component of complement (C8). In a review of the literature, recurrent infection occurred in six of 13 children with complement deficiency, four of whom had serotyping positive for N. meningitidis, group Y. Screening for complement deficiency is recommended for all children with meningococcal disease due to N. meningitidis, group Y, and for any child with recurrent infection due to any Neisseria species.

References

Aug 1, 1977·American Journal of Clinical Pathology·P G BernadM Levey
Sep 1, 1977·American Journal of Diseases of Children·R S Baltimore, M Hammerschlag
Feb 1, 1978·American Journal of Clinical Pathology·J Amico, R L Myerowitz
Jun 1, 1974·The American Journal of the Medical Sciences·J A Risko, G R Hodges
Dec 1, 1974·Annals of Internal Medicine·J D Smilack
Jul 1, 1981·The Journal of Pediatrics·T J LehmanK King
Apr 21, 1983·The New England Journal of Medicine·R T EllisonL B Reller
Oct 1, 1981·The Journal of Pediatrics·M S Edwards, C J Baker
Nov 1, 1981·The Journal of Infectious Diseases·M H VeederT J Lee
Jul 1, 1980·Archives of Internal Medicine·J D CloughW E Braun

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Citations

Jun 1, 1989·European Journal of Pediatrics·M CeccarelliC Ughi
Nov 4, 2000·Biochimica Et Biophysica Acta·S Xu, P Venge
Jul 1, 1991·Clinical Microbiology Reviews·J E Figueroa, P Densen

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