Relapsing neuromyelitis optica: demographic and clinical features in Iranian patients

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
M A SahraianM Mohammad Ebrahim

Abstract

Neuromyelitis Optica (NMO) is a severe inflammatory demyelinating disease of the central nervous system with distinguishing features from multiple sclerosis (MS). NMO has an unknown etiology with poor prognosis in which anti-aquaporin-4 receptor IgG seems to play a major role. The purpose of this study is to represent a clinical and demographic data of NMO in Iranian population. Of 1800 patients attending our MS clinic, 44 patients with NMO were recruited from 2006 to 2009. Female to male ratio was 3:1 and the disease affected women in younger ages than men (P = 0.04). The median expanded disability status scale score was 3 and the mean duration of symptoms was 4.53 +/- 3.41 (median = 4) years with annual relapse rate of 1.13 year/patient. The most frequent symptoms at presentation were optic neuritis 22 (50%) and transverse myelitis 14 (31.8%). Out of 12 patients whose titer of NMO-IgG was measured, four (30.7%) patients were seropositive. Twenty-eight patients (63%) received azathioprine for a mean duration of 16.84 +/- 27.91 months with significantly lower annual relapse rate (0.4 year/patient). Iranian patients as a Caucasian population living in Asia seem to have the same clinical features in comparison with the reported s...Continue Reading

References

Apr 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·J I O'RiordanD H Miller
Sep 25, 1999·Neurology·D M WingerchukB G Weinshenker
May 9, 2002·Journal of the Neurological Sciences·J de SezeP Vermersch
Jun 22, 2002·Brain : a Journal of Neurology·Claudia F LucchinettiHans Lassmann
Sep 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·R M Papais-AlvarengaC M Poser
Oct 30, 2003·Multiple Sclerosis : Clinical and Laboratory Research·J de SezeP Vermersch
Dec 20, 2003·Nature Reviews. Neuroscience·Mahmood Amiry-Moghaddam, Ole P Ottersen
Mar 5, 2004·Journal of Neurology·Angelo GhezziUNKNOWN Italian Devic's Study Group (IDESG)
Jun 17, 2004·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jacqueline Bakker, Luanne Metz
Dec 30, 2004·Neurology·Jorge Correale, Marcela Fiol
Jan 22, 2005·Neurologic Clinics·Orhun H Kantarci, Brian G Weinshenker
Aug 10, 2005·The Journal of Experimental Medicine·Vanda A LennonShannon R Hinson
Mar 1, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·I NakashimaY Itoyama
May 24, 2006·Neurology·D M WingerchukB G Weinshenker
Jul 13, 2006·Archives of Neurology·Bianca Weinstock-GuttmanRohit Bakshi
Jul 13, 2006·Archives of Neurology·Sean J PittockVanda A Lennon
Aug 21, 2007·Lancet Neurology·Dean M WingerchukBrian G Weinshenker
Feb 20, 2008·Journal of Neurology·John Flores RiveraTeresa Corona V
Mar 22, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·J-S WuA G Kermode
Jun 25, 2008·Multiple Sclerosis : Clinical and Laboratory Research·B Weinstock-GuttmanM Ramanathan
Jul 22, 2008·Arquivos de neuro-psiquiatria·Tarso AdoniDagoberto Callegaro
Oct 24, 2008·Brain : a Journal of Neurology·S JariusW Kristoferitsch
Nov 8, 2008·Annals of the New York Academy of Sciences·Jun-ichi Kira

❮ Previous
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Citations

Nov 2, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J A Cabrera-Gomez, I Kister
Aug 13, 2014·Nature Reviews. Neurology·Marios C PapadopoulosAlan S Verkman
Nov 26, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ingo Kleiter, Ralf Gold
Nov 29, 2012·Neurologic Clinics·Mohammad Ali SahraianAlireza Minagar
Oct 1, 2012·Multiple Sclerosis and Related Disorders·Dorlan J KimbroughUNKNOWN GJCF-CC&BR
May 31, 2011·Autoimmunity Reviews·Andrea T Borchers, M Eric Gershwin
Apr 27, 2010·Clinical Neurology and Neurosurgery·Mohammad Ali Sahraian, Arman Eshaghi
Jun 9, 2015·Journal of the Neurological Sciences·Wildéa Lice de Carvalho Jennings PereiraDamacio Ramón Kaimen-Maciel
Mar 8, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Joanna KitleyJackie Palace
Feb 14, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nirmeen A KishkNagwa Ahmed
Jun 17, 2016·Acta neurologica Belgica·Ameneh Zare-ShahabadiSeyed Mohammad Baghbanian
Jun 5, 2016·Continuum : Lifelong Learning in Neurology·Ilana Katz Sand
Feb 18, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Markus C KowarikJeffrey L Bennett
Oct 5, 2020·Journal of Neurology·Trygve HolmøyØivind Torkildsen
Dec 7, 2020·Multiple Sclerosis and Related Disorders·Soto de Castillo IbisFreda Hernandez
Dec 16, 2020·Multiple Sclerosis and Related Disorders·Mahdi BarzegarNasrin Asgari
Jun 21, 2020·Multiple Sclerosis and Related Disorders·Correa-Díaz Edgar PatricioGualotuña Pachacama Wilson Alfredo

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