Related donor hematopoietic stem cell transplantation for Fanconi anemia without radiation: a single center experience in Turkey

Pediatric Transplantation
Mehmet ErtemSevgi Gozdasoglu

Abstract

Eight children with FA underwent allogeneic HSCT without using irradiation for the conditioning regimen. Patients received two different conditioning regimens: first two patients received BU 1.5 mg/kg/day for four days and CY 10 mg/kg/day for four days and the other regimen was: Flu 30 mg/m(2)/day for five days, CY 10 mg/kg/day for two days, and ATG-Fresenius 9-10 mg/kg/day for four days. GVHD prophylaxis consisted of CsA + MTX for the first two patients and only CsA for the others. All patients received HLA-identical stem cells from related donors. Primary engraftment was demonstrated in all patients. No patient developed acute GVHD and one patient had chronic GVHD. Only one patient who received BU based regimen died because of VOD. Overall, seven patients (87.5%) are alive with stable full donor chimerism at a median follow-up time of 2.5 yr (range: 1.7-8.9 yr). None of the patients developed secondary malignancy. Based on our data, we conclude that Flu-based, non-irradiation conditioning regimen was safe with low organ toxicity and stable engraftment in FA patients undergoing HSCT from matched related donors.

References

Dec 1, 1992·British Journal of Haematology·G J CreemersA Hagenbeek
Sep 21, 1989·The New England Journal of Medicine·R P WitherspoonR Storb
Oct 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S I BearmanE D Thomas
Aug 1, 1980·British Journal of Haematology·E GluckmanJ Bernard
Aug 1, 1980·British Journal of Haematology·R BergerC Gisselbrecht
Mar 27, 1997·The New England Journal of Medicine·R E CurtisJ D Boice
Feb 18, 1998·Bone Marrow Transplantation·J KapelushnikA Nagler
Jun 11, 1999·Journal of Pediatric Hematology/oncology·M AkerA Nagler
Jan 19, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G SociéM M Horowitz
Aug 5, 2000·Bone Marrow Transplantation·M ErtemA Ikincioğullari
Oct 24, 2002·Blood·Philip S RosenbergBlanche P Alter
Jan 15, 2003·Archives of Otolaryngology--head & Neck Surgery·David I KutlerBhuvanesh Singh
Apr 3, 2004·Blood·Philip S RosenbergBlanche P Alter
Jun 21, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·M BitanS Slavin
Jul 11, 2006·Seminars in Hematology·Grover C Bagby, Blanche P Alter

❮ Previous
Next ❯

Citations

Feb 9, 2010·British Journal of Haematology·Margaret L MacMillan, John E Wagner
Jan 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Margaret L MacMillanGeorge Q Daley
Jan 12, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Polina StepenskyIgor B Resnick
Nov 14, 2012·Expert Review of Hematology·Angela R Smith, John E Wagner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Carmem BonfimRicardo Pasquini
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Ricardo PasquiniJohn E Wagner
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Eliane GluckmanEurocord-Netcord and EBMT
© 2022 Meta ULC. All rights reserved