Relatedness in the post-genomic era: is it still useful?

Nature Reviews. Genetics
Doug Speed, David J Balding

Abstract

Relatedness is a fundamental concept in genetics but is surprisingly hard to define in a rigorous yet useful way. Traditional relatedness coefficients specify expected genome sharing between individuals in pedigrees, but actual genome sharing can differ considerably from these expected values, which in any case vary according to the pedigree that happens to be available. Nowadays, we can measure genome sharing directly from genome-wide single-nucleotide polymorphism (SNP) data; however, there are many such measures in current use, and we lack good criteria for choosing among them. Here, we review SNP-based measures of relatedness and criteria for comparing them. We discuss how useful pedigree-based concepts remain today and highlight opportunities for further advances in quantitative genetics, with a focus on heritability estimation and phenotype prediction.

References

Oct 1, 1975·Annals of Human Genetics·E A Thompson
Oct 1, 1991·Genetical Research·M Slatkin
Mar 1, 1996·Human Heredity·S W Guo
Jul 13, 2006·Nature Genetics·William ValdarJonathan Flint
Sep 20, 2006·Nature Reviews. Genetics·Bruce S WeirAmanda B Hepler
May 4, 2007·Human Heredity·J H BarrettM D Teare
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Jul 5, 2007·Human Genetics·Jan GraffelmanJaume Bertranpetit
Aug 7, 2007·Nature Genetics·Sung KimMagnus Nordborg
Dec 14, 2007·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M E Goddard, B J Hayes
Feb 20, 2008·Theoretical Population Biology·E A Thompson
May 22, 2008·Genetics·Federico C F CalboliDavid J Balding
May 24, 2008·PLoS Genetics·Garrett HellenthalDaniel Falush
Oct 24, 2008·Journal of Dairy Science·P M VanRaden
Oct 31, 2008·Genome Research·Alexander GusevItsik Pe'er
Jan 24, 2009·Journal of Dairy Science·B J HayesM E Goddard
Jan 24, 2009·Nature Genetics·Augustine KongKari Stefansson
Feb 10, 2009·American Journal of Human Genetics·Brian L Browning, Sharon R Browning
Feb 4, 2010·PLoS Biology·Samuel P DicksonDavid B Goldstein
Apr 3, 2010·Nature·UNKNOWN Wellcome Trust Case Control ConsortiumPeter Donnelly
Jun 22, 2010·Nature Genetics·Jian YangPeter M Visscher
Sep 30, 2010·Nature Reviews. Genetics·Joseph E PowellMichael E Goddard
Oct 12, 2010·Bioinformatics·Ani ManichaikulWei-Min Chen
Nov 4, 2010·Nature Reviews. Genetics·Gustavo de los CamposDavid B Allison
Nov 9, 2010·Genetic Epidemiology·Yun LiGonçalo R Abecasis
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Feb 12, 2011·American Journal of Human Genetics·Brian L Browning, Sharon R Browning
Mar 8, 2011·American Journal of Human Genetics·Sang Hong LeePeter M Visscher
May 10, 2011·Nature Genetics·Jian YangPeter M Visscher
May 10, 2011·PLoS Genetics·Robert MakowskyGustavo de los Campos

❮ Previous
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Citations

Apr 7, 2016·Biodemography and Social Biology·Benjamin W DomingueJason D Boardman
Nov 13, 2015·BMC Bioinformatics·David Edwards
Aug 19, 2016·Journal of Human Genetics·Jacklyn N HellwegeDonald W Bowden
Sep 3, 2016·PLoS Genetics·Marco ScutariDavid Balding
Sep 21, 2016·Ecology and Evolution·Veronika Städele, Linda Vigilant
Sep 28, 2016·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·C A García-BaccinoR J C Cantet
May 15, 2015·BMC Bioinformatics·Héloïse GauvinMarie-Hélène Roy-Gagnon
Apr 8, 2017·PLoS Genetics·Tian GeJordan W Smoller
Nov 7, 2016·Human Genetics·Francesc Calafell, Maarten H D Larmuseau
May 23, 2017·Nature Genetics·Doug SpeedDavid J Balding
May 27, 2017·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Vincent GarinFred van Eeuwijk
Apr 19, 2018·Molecular Ecology Resources·René M MalenfantDavid W Coltman
Nov 22, 2017·Molecular Ecology Resources·Catherine R M AttardLuciana M Möller
Dec 23, 2017·Molecular Ecology Resources·Pablo A S FonsecaMaria Raquel S Carvalho
Sep 15, 2017·Human Heredity·Jonathan T L KangNoah A Rosenberg
Aug 15, 2018·Molecular Ecology·Jérôme GoudetBruce S Weir
Jan 23, 2019·Genome Biology·Matthew E B HansenSarah A Tishkoff
Nov 30, 2018·G3 : Genes - Genomes - Genetics·Zhi XiongQuan Long
Mar 21, 2019·Proceedings. Biological Sciences·Claire Dandine-RoullandRaphaëlle Chaix
Sep 14, 2018·Heredity·Ceferino Varón-González, Nicolas Navarro
Aug 18, 2016·Animal : an International Journal of Animal Bioscience·H LiuA C Sørensen
May 10, 2019·PLoS Genetics·Tal ShorOmer Weissbrod
Aug 1, 2015·Behavior Genetics·Benjamin W DomingueJason D Boardman
May 6, 2019·Molecular Ecology Resources·Vivienne ForoughiradCéline H Frère
May 3, 2019·Genetic Epidemiology·Elizabeth A Thompson
Feb 27, 2018·Physiological Reports·Ana I Hernandez CorderoArimantas Lionikas
May 28, 2019·Plant Biotechnology Journal·Yanru CuiShizhong Xu
May 28, 2017·Genetics·Bruce S Weir, Jérôme Goudet
Jan 18, 2020·PLoS Biology·Patrick K Albers, Gil McVean
Jul 21, 2020·Physiological Genomics·Oliver HinesYalda Jamshidi
Sep 29, 2019·Genetics, Selection, Evolution : GSE·Harmen P DoekesJack J Windig
Oct 16, 2015·Molecular Ecology·M C CastellanosJ G Pausas
Nov 24, 2016·Evolutionary Applications·Marty KardosFred W Allendorf

❮ Previous
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