Relatedness of glycoproteins expressed on the surface of simian herpes-virus virions and infected cells to specific HSV glycoproteins.

Archives of Virology
R EberleJ K Hilliard

Abstract

The antigenic relatedness of the surface glycoprotein antigens of six herpesviruses indigenous to human and nonhuman primates was examined. Binding of anti-viral sera to viral antigens expressed on the surface of infected cells demonstrated that the surface antigens of herpes simplex virus type 1 (HSV 1), HSV 2, simian agent 8 (SA8), and Herpesvirus simiae (B virus) exhibit extensive cross-reactivity. Surface antigens of two viruses isolated from South American primates, H. saimiri 1 (HVS 1) and H. ateles 1 (HVA 1), were comparatively more virus-specific in their antigenic reactivity. Endpoint neutralization tests performed in the presence and absence of complement confirmed these results. Immunoprecipitation of viral proteins was used to identify those representing cross-reactive surface antigens. A glycoprotein of approximately 110,000-125,000 Daltons (110-125 k) was immunoprecipitated from cells infected with each of the six primate herpesvirus by antisera to each of the viruses. Using monospecific antisera, these glycoproteins were shown to be antigenically related to the gB glycoproteins of HSV. Although these glycoproteins were antigenically conserved among all six viruses, antibodies to the gB glycoproteins did not cross...Continue Reading

References

Oct 1, 1977·The Journal of General Virology·R W Honess, D H Watson
Oct 1, 1976·Virology·J M Walboomers, J T Schegget
Jan 1, 1989·Archives of Virology·J K HilliardR Eberle
Feb 1, 1985·Journal of Virology·R J EisenbergG H Cohen
Sep 1, 1986·The Journal of General Virology·A J Davison, J E Scott
Jan 1, 1968·Archiv für die gesamte Virusforschung·Y UedaK Shiroki
Oct 1, 1972·Virology·U Olshevsky, Y Becker
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G T LeeP G Spear
May 1, 1983·The Journal of Infectious Diseases·L C GoldsteinR C Nowinski
Nov 1, 1980·Infection and Immunity·M J LawmanB T Rouse
Jan 1, 1984·Laboratory Animals·H T Zwartouw, E A Boulter

❮ Previous
Next ❯

Citations

Jan 1, 1989·Archives of Virology·J K HilliardR Eberle
Jan 1, 1992·Archives of Virology·L M CropperD Brown
Jan 1, 1995·Archives of Virology·R EberleJ K Hilliard
Jan 1, 1991·Comparative Immunology, Microbiology and Infectious Diseases·K Borchers, H Ludwig
Nov 1, 1993·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·K Borchers, M Ozel
Aug 30, 2001·Journal of Clinical Microbiology·K TanabayashiA Yamada
May 8, 2004·Journal of Clinical Microbiology·Chika OyaRyo Hondo
Feb 8, 2005·Journal of Clinical Microbiology·Ludmila PerelyginaJulia Hilliard
Mar 8, 2008·ILAR Journal·William R MortonRichard F Grant
Dec 7, 2010·Virology·Shaun TylerR Eberle
Jan 1, 1990·Archives of Virology·K BorchersH Ludwig
Apr 19, 2018·Advances in Virology·R Eberle, L Jones-Engel
Aug 1, 1991·Journal of Virology·S L HighlanderJ C Glorioso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.